Cargando…

3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide with limited treatment options. Biomarker-based active phenolic flavonoids isolated from medicinal plants might shed some light on potential therapeutics for treating HCC. 3,3′-diindolylmethane (DIM) is a unique bi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Munakarmi, Suvesh, Shrestha, Juna, Shin, Hyun-Beak, Lee, Geum-Hwa, Jeong, Yeon-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151225/ https://www.ncbi.nlm.nih.gov/pubmed/34066056 http://dx.doi.org/10.3390/cells10051178

Ejemplares similares

Hepatoprotective Effects of a Natural Flavanol 3,3′-Diindolylmethane against CCl(4)-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade
por: Munakarmi, Suvesh, et al.
Publicado: (2022)

Anticancer effects of Poncirus fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion
por: Munakarmi, Suvesh, et al.
Publicado: (2020)

Synergistic Effects of Vitis vinifera L. and Centella asiatica against CCl(4)-Induced Liver Injury in Mice
por: Munakarmi, Suvesh, et al.
Publicado: (2023)

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress
por: Munakarmi, Suvesh, et al.
Publicado: (2020)

3,3’-Diindolylmethane induces apoptosis and autophagy in fission yeast
por: Emami, Parvaneh, et al.
Publicado: (2021)

Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3′-diindolylmethane through the mitochondrial pathway
por: Nachshon-Kedmi, M, et al.
Publicado: (2004)

3,3′-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis
por: Luo, Qiang, et al.
Publicado: (2018)

3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation
por: Wang, Wenjing, et al.
Publicado: (2015)

Cellular and Molecular Mechanisms of 3,3′-Diindolylmethane in Gastrointestinal Cancer
por: Kim, Soo Mi
Publicado: (2016)

3′3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling
por: Li, Wen-Xue, et al.
Publicado: (2015)

Interactions between β-Lactoglobulin and 3,3′-Diindolylmethane in Model System
por: Wang, Cuina, et al.
Publicado: (2019)

Amelioration of Hyperglycemia-Induced Nephropathy by 3,3′-Diindolylmethane in Diabetic Mice
por: Choi, Kyeong-Mi, et al.
Publicado: (2019)

3,3′-Diindolylmethane Induces G(1) Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells
por: Shorey, Lyndsey E., et al.
Publicado: (2012)

3,3′-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species
por: Lanza-Jacoby, Susan, et al.
Publicado: (2018)

Physicochemical and Microstructural Properties of Polymerized Whey Protein Encapsulated 3,3′-Diindolylmethane Nanoparticles
por: Khan, Abbas, et al.
Publicado: (2019)

Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells
por: Gao, Xiang, et al.
Publicado: (2020)

Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
por: Williams, David E.
Publicado: (2021)

The Indolic Diet-Derivative, 3,3′-Diindolylmethane, Induced Apoptosis in Human Colon Cancer Cells through Upregulation of NDRG1
por: Lerner, A., et al.
Publicado: (2012)

Anticancer effects of 3,3′-diindolylmethane are associated with G1 arrest and mitochondria-dependent apoptosis in human nasopharyngeal carcinoma cells
por: XU, YU, et al.
Publicado: (2013)

Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis
por: Li, Yiwei, et al.
Publicado: (2012)

Role of BioResponse 3,3′-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience
por: Li, Yiwei, et al.
Publicado: (2016)

Molecular Simulation Studies of 3,3′-Diindolylmethane as a Potent MicroRNA-21 Antagonist
por: Junaid, Md., et al.
Publicado: (2017)

3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer
por: Zhang, Jieping, et al.
Publicado: (2022)

2,2′-Diphenyl-3,3′-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway
por: Bhowmik, Arijit, et al.
Publicado: (2013)

3,3’-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer
por: Xiang, Fenfen, et al.
Publicado: (2021)

3,3'-Diindolylmethane plus Eflornithine suppress DNA Replication and Cell Cycle in Esophageal Squamous Cell Carcinoma in vivo
por: Ma, Fayang, et al.
Publicado: (2022)

Comparative preclinical pharmacokinetics study of 3,3′-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?
por: Paltsev, Mikhail, et al.
Publicado: (2013)

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro
por: Xia, Zun-En, et al.
Publicado: (2018)

3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm
por: Baruch, Yifat, et al.
Publicado: (2023)

3,3′Diindolylmethane Suppresses Vascular Smooth Muscle Cell Phenotypic Modulation and Inhibits Neointima Formation after Carotid Injury
por: Guan, Hongjing, et al.
Publicado: (2012)

Estrogen Induced Metastatic Modulators MMP-2 and MMP-9 Are Targets of 3,3′-Diindolylmethane in Thyroid Cancer
por: Rajoria, Shilpi, et al.
Publicado: (2011)

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth
por: Yin, Xiao-Fei, et al.
Publicado: (2012)

Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis
por: Femia, Angelo Pietro, et al.
Publicado: (2015)

The Anticancer Agent 3,3'-Diindolylmethane Inhibits Multispecies Biofilm Formation by Acne-Causing Bacteria and Candida albicans
por: Kim, Yong-Guy, et al.
Publicado: (2022)

The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling
por: Rzemieniec, J., et al.
Publicado: (2019)

3,3′-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells
por: Lee, Bo Dam, et al.
Publicado: (2019)

3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy
por: Tang, Hao, et al.
Publicado: (2022)

Attenuation of Carcinogenesis and the Mechanism Underlying by the Influence of Indole-3-carbinol and Its Metabolite 3,3′-Diindolylmethane: A Therapeutic Marvel
por: Maruthanila, V. L., et al.
Publicado: (2014)

3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition
por: WU, TINGTING, et al.
Publicado: (2014)

BRCA1 mRNA levels following a 4–6-week intervention with oral 3,3′-diindolylmethane
por: Kotsopoulos, J, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_r35eftj1njpaiii7dh9t16eg82