α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation

Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine (DFMO) induces cytostasis that occurs in two phases; the early phase which can be reversed by spermidine, spermine, and some of their analogs, and...

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Detalles Bibliográficos
Autores principales: Hyvönen, Mervi T., Khomutov, Maxim, Vepsäläinen, Jouko, Khomutov, Alex R., Keinänen, Tuomo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151227/
https://www.ncbi.nlm.nih.gov/pubmed/34068700
http://dx.doi.org/10.3390/biom11050707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151227/
https://www.ncbi.nlm.nih.gov/pubmed/34068700
http://dx.doi.org/10.3390/biom11050707

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