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Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers

The FTO A/T polymorphism (rs9939609) has been strongly associated with body mass-related traits in nonathletic populations, but rarely with elite athletic performance. The aim of the study was to investigate the association between the A/T polymorphism and athlete status in elite swimmers. Polish sw...

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Autores principales: Zmijewski, Piotr, Leońska-Duniec, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151273/
https://www.ncbi.nlm.nih.gov/pubmed/34064570
http://dx.doi.org/10.3390/genes12050715
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author Zmijewski, Piotr
Leońska-Duniec, Agata
author_facet Zmijewski, Piotr
Leońska-Duniec, Agata
author_sort Zmijewski, Piotr
collection PubMed
description The FTO A/T polymorphism (rs9939609) has been strongly associated with body mass-related traits in nonathletic populations, but rarely with elite athletic performance. The aim of the study was to investigate the association between the A/T polymorphism and athlete status in elite swimmers. Polish swimmers (n = 196) who competed in national and international competition at short- (SDS; 50–200 m; n = 147) and long-distance events (LDS; ≥400 m; n = 49) were recruited. The control group included 379 unrelated, sedentary young participants. The participants were all Caucasians. Genotyping was carried out using real-time PCR. It was found that the chance of being an elite swimmer was lower in carriers of the AT and AA genotype compared with TT homozygotes (1.5 and 2.0 times, respectively). These findings were confirmed in an allelic association; the A allele was less frequent in the swimmers compared with controls (p = 0.004). However, when SDS were compared against LDS, no significant differences were observed in genotypic and allelic distribution. The results of our experiment suggest that the variation within the FTO gene can affect elite athlete status. It was demonstrated that harboring the T allele may be beneficial for achieving success in a sport such as swimming.
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spelling pubmed-81512732021-05-27 Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers Zmijewski, Piotr Leońska-Duniec, Agata Genes (Basel) Article The FTO A/T polymorphism (rs9939609) has been strongly associated with body mass-related traits in nonathletic populations, but rarely with elite athletic performance. The aim of the study was to investigate the association between the A/T polymorphism and athlete status in elite swimmers. Polish swimmers (n = 196) who competed in national and international competition at short- (SDS; 50–200 m; n = 147) and long-distance events (LDS; ≥400 m; n = 49) were recruited. The control group included 379 unrelated, sedentary young participants. The participants were all Caucasians. Genotyping was carried out using real-time PCR. It was found that the chance of being an elite swimmer was lower in carriers of the AT and AA genotype compared with TT homozygotes (1.5 and 2.0 times, respectively). These findings were confirmed in an allelic association; the A allele was less frequent in the swimmers compared with controls (p = 0.004). However, when SDS were compared against LDS, no significant differences were observed in genotypic and allelic distribution. The results of our experiment suggest that the variation within the FTO gene can affect elite athlete status. It was demonstrated that harboring the T allele may be beneficial for achieving success in a sport such as swimming. MDPI 2021-05-11 /pmc/articles/PMC8151273/ /pubmed/34064570 http://dx.doi.org/10.3390/genes12050715 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zmijewski, Piotr
Leońska-Duniec, Agata
Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title_full Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title_fullStr Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title_full_unstemmed Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title_short Association between the FTO A/T Polymorphism and Elite Athlete Status in Caucasian Swimmers
title_sort association between the fto a/t polymorphism and elite athlete status in caucasian swimmers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151273/
https://www.ncbi.nlm.nih.gov/pubmed/34064570
http://dx.doi.org/10.3390/genes12050715
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AT leonskaduniecagata associationbetweentheftoatpolymorphismandeliteathletestatusincaucasianswimmers