Cargando…

Akt Kinase Intervenes in Flavivirus Replication by Interacting with Viral Protein NS5

Arthropod-borne flaviviruses, such as Zika virus (ZIKV), Usutu virus (USUV), and West Nile virus (WNV), are a growing cause of human illness and death around the world. Presently, no licensed antivirals to control them are available and, therefore, search for broad-spectrum antivirals, including hos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Albentosa-González, Laura, Jimenez de Oya, Nereida, Arias, Armando, Clemente-Casares, Pilar, Martin-Acebes, Miguel Ángel, Saiz, Juan Carlos, Sabariegos, Rosario, Mas, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151281/ https://www.ncbi.nlm.nih.gov/pubmed/34066055 http://dx.doi.org/10.3390/v13050896

Ejemplares similares

Akt Interacts with Usutu Virus Polymerase, and Its Activity Modulates Viral Replication
por: Albentosa-González, Laura, et al.
Publicado: (2021)

Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein
por: Albentosa-González, L., et al.
Publicado: (2019)

Akt Phosphorylation of Hepatitis C Virus NS5B Regulates Polymerase Activity and Hepatitis C Virus Infection
por: Sabariegos, Rosario, et al.
Publicado: (2021)

Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
por: Martín-Acebes, Miguel A., et al.
Publicado: (2019)

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus
por: Vázquez-Calvo, Ángela, et al.
Publicado: (2017)

West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids
por: Martín-Acebes, Miguel A., et al.
Publicado: (2011)

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication
por: Li, Xiao-Dan, et al.
Publicado: (2014)

Antibody-Dependent Enhancement and Zika: Real Threat or Phantom Menace?
por: Martín-Acebes, Miguel A., et al.
Publicado: (2018)

Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus
por: Martín-Acebes, Miguel A., et al.
Publicado: (2020)

Novel Nonnucleoside Inhibitors of Zika Virus Polymerase Identified through the Screening of an Open Library of Antikinetoplastid Compounds
por: Sáez-Álvarez, Yanira, et al.
Publicado: (2021)

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models
por: Jiménez de Oya, Nereida, et al.
Publicado: (2019)

Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation
por: Ci, Yali, et al.
Publicado: (2021)

Flavivirus NS1 and Its Potential in Vaccine Development
por: Carpio, Kassandra L., et al.
Publicado: (2021)

The Role of NS1 Protein in the Diagnosis of Flavivirus Infections
por: Fisher, Ron, et al.
Publicado: (2023)

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools
por: Sabariegos, Rosario, et al.
Publicado: (2022)

Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus
por: Saiz, Juan-Carlos, et al.
Publicado: (2018)

Current Progress of Avian Vaccines Against West Nile Virus
por: Jiménez de Oya, Nereida, et al.
Publicado: (2019)

Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
por: Bollati, Michela, et al.
Publicado: (2010)

Flavivirus NS1: a multifaceted enigmatic viral protein
por: Rastogi, Meghana, et al.
Publicado: (2016)

Suppression of Type I Interferon Signaling by Flavivirus NS5
por: Thurmond, Stephanie, et al.
Publicado: (2018)

Structural basis for STAT2 suppression by flavivirus NS5
por: Wang, Boxiao, et al.
Publicado: (2020)

Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy
por: Blázquez, Ana-Belén, et al.
Publicado: (2014)

Pathogenicity and virulence of West Nile virus revisited eight decades after its first isolation
por: Saiz, Juan-Carlos, et al.
Publicado: (2021)

Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review
por: Wahaab, Abdul, et al.
Publicado: (2021)

A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds
por: Martín-Acebes, Miguel A., et al.
Publicado: (2013)

2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase
por: Dong, Hongping, et al.
Publicado: (2012)

The flavivirus polymerase NS5 regulates translation of viral genomic RNA
por: Fajardo, Teodoro, et al.
Publicado: (2020)

An Antiviral Peptide from Alopecosa nagpag Spider Targets NS2B–NS3 Protease of Flaviviruses
por: Ji, Mengyao, et al.
Publicado: (2019)

The IMPORTance of the Nucleus during Flavivirus Replication
por: Lopez-Denman, Adam J., et al.
Publicado: (2017)

Inhibitors compounds of the flavivirus replication process
por: García, Leidy L., et al.
Publicado: (2017)

Molecular Insights into the Flavivirus Replication Complex
por: van den Elsen, Kaïn, et al.
Publicado: (2021)

A Recombinant Subviral Particle-Based Vaccine Protects Magpie (Pica pica) Against West Nile Virus Infection
por: Jiménez de Oya, Nereida, et al.
Publicado: (2019)

A conserved arginine in NS5 binds genomic 3′ stem–loop RNA for primer-independent initiation of flavivirus RNA replication
por: Wang, Sai, et al.
Publicado: (2022)

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1
por: Avirutnan, Panisadee, et al.
Publicado: (2010)

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen
por: Le Breton, Marc, et al.
Publicado: (2011)

Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil
por: Maruyama, Sandra Regina, et al.
Publicado: (2013)

Replication-Independent Generation and Morphological Analysis of Flavivirus Replication Organelles
por: Goellner, Sarah, et al.
Publicado: (2020)

A Vaccine Based on a Modified Vaccinia Virus Ankara Vector Expressing Zika Virus Structural Proteins Controls Zika Virus Replication in Mice
por: Pérez, Patricia, et al.
Publicado: (2018)

Response: Commentary: Zika Virus: the Latest Newcomer
por: Saiz, Juan-Carlos, et al.
Publicado: (2016)

Zika virus infection confers protection against West Nile virus challenge in mice
por: Vázquez-Calvo, Ángela, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uij3f57ppusmiihtkjjm86e2pd