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Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors

Background: The 14q32 cluster is among the largest polycistronic miRNA clusters. miRNAs encoded here have been implicated in tumorigenesis of multiple organs including endocrine glands. Methods: Critical review of miRNA studies performed in endocrine tumors have been performed. The potential relevan...

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Autores principales: Krokker, Lilla, Patócs, Attila, Butz, Henriett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151414/
https://www.ncbi.nlm.nih.gov/pubmed/34066712
http://dx.doi.org/10.3390/genes12050698
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author Krokker, Lilla
Patócs, Attila
Butz, Henriett
author_facet Krokker, Lilla
Patócs, Attila
Butz, Henriett
author_sort Krokker, Lilla
collection PubMed
description Background: The 14q32 cluster is among the largest polycistronic miRNA clusters. miRNAs encoded here have been implicated in tumorigenesis of multiple organs including endocrine glands. Methods: Critical review of miRNA studies performed in endocrine tumors have been performed. The potential relevance of 14q32 miRNAs through investigating their targets, and integrating the knowledge provided by literature data and bioinformatics predictions have been indicated. Results: Pituitary adenoma, papillary thyroid cancer and a particular subset of pheochromocytoma and adrenocortical cancer are characterized by the downregulation of miRNAs encoded by the 14q32 cluster. Pancreas neuroendocrine tumors, most of the adrenocortical cancer and medullary thyroid cancer are particularly distinct, as 14q32 miRNAs were overexpressed. In pheochromocytoma and growth-hormone producing pituitary adenoma, however, both increased and decreased expression of 14q32 miRNAs cluster members were observed. In the background of this phenomenon methodological, technical and biological factors are hypothesized and discussed. The functions of 14q32 miRNAs were also revealed by bioinformatics and literature data mining. Conclusions: 14q32 miRNAs have a significant role in the tumorigenesis of endocrine organs. Regarding their stable expression in the circulation of healthy individuals, further investigation of 14q32 miRNAs could provide a potential for use as biomarkers (diagnostic or prognostic) in endocrine neoplasms.
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spelling pubmed-81514142021-05-27 Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors Krokker, Lilla Patócs, Attila Butz, Henriett Genes (Basel) Review Background: The 14q32 cluster is among the largest polycistronic miRNA clusters. miRNAs encoded here have been implicated in tumorigenesis of multiple organs including endocrine glands. Methods: Critical review of miRNA studies performed in endocrine tumors have been performed. The potential relevance of 14q32 miRNAs through investigating their targets, and integrating the knowledge provided by literature data and bioinformatics predictions have been indicated. Results: Pituitary adenoma, papillary thyroid cancer and a particular subset of pheochromocytoma and adrenocortical cancer are characterized by the downregulation of miRNAs encoded by the 14q32 cluster. Pancreas neuroendocrine tumors, most of the adrenocortical cancer and medullary thyroid cancer are particularly distinct, as 14q32 miRNAs were overexpressed. In pheochromocytoma and growth-hormone producing pituitary adenoma, however, both increased and decreased expression of 14q32 miRNAs cluster members were observed. In the background of this phenomenon methodological, technical and biological factors are hypothesized and discussed. The functions of 14q32 miRNAs were also revealed by bioinformatics and literature data mining. Conclusions: 14q32 miRNAs have a significant role in the tumorigenesis of endocrine organs. Regarding their stable expression in the circulation of healthy individuals, further investigation of 14q32 miRNAs could provide a potential for use as biomarkers (diagnostic or prognostic) in endocrine neoplasms. MDPI 2021-05-08 /pmc/articles/PMC8151414/ /pubmed/34066712 http://dx.doi.org/10.3390/genes12050698 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Krokker, Lilla
Patócs, Attila
Butz, Henriett
Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title_full Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title_fullStr Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title_full_unstemmed Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title_short Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors
title_sort essential role of the 14q32 encoded mirnas in endocrine tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151414/
https://www.ncbi.nlm.nih.gov/pubmed/34066712
http://dx.doi.org/10.3390/genes12050698
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