Effects of Propolis on Infectious Diseases of Medical Relevance

SIMPLE SUMMARY: Propolis is a beekeeping product with a complex and highly variable chemical composition. Many beneficial health properties have been reported. In this review, we will be focusing on compiling the studies carried out with propolis on infectious diseases of greater medical relevance. Likewise, the promises and challenges that propolis has to consolidate itself as a complementary therapy for the treatment of these diseases are analyzed. ABSTRACT: Infectious diseases are a significant problem affecting the public health and economic stability of societies all over the world. Treatment is available for most of these diseases; however, many pathogens have developed resistance to drugs, necessitating the development of new therapies with chemical agents, which can have serious side effects and high toxicity. In addition, the severity and aggressiveness of emerging and re-emerging diseases, such as pandemics caused by viral agents, have led to the priority of investigating new therapies to complement the treatment of different infectious diseases. Alternative and complementary medicine is widely used throughout the world due to its low cost and easy access and has been shown to provide a wide repertoire of options for the treatment of various conditions. In this work, we address the relevance of the effects of propolis on the causal pathogens of the main infectious diseases with medical relevance; the existing compiled information shows that propolis has effects on Gram-positive and Gram-negative bacteria, fungi, protozoan parasites and helminths, and viruses; however, challenges remain, such as the assessment of their effects in clinical studies for adequate and safe use.