Cargando…

LIMK2-NKX3.1 Engagement Promotes Castration-Resistant Prostate Cancer

SIMPLE SUMMARY: Prostate cancer is the principal cause of cancer-related mortality in men. While localized tumors can be successfully treated by orchiectomy or medical castration, most of the patients ultimately progress to the castration-resistant prostate cancer (CRPC) stage, which is incurable at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sooreshjani, Moloud A., Nikhil, Kumar, Kamra, Mohini, Nguyen, Dung N., Kumar, Dinesh, Shah, Kavita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151535/ https://www.ncbi.nlm.nih.gov/pubmed/34066036 http://dx.doi.org/10.3390/cancers13102324

Ejemplares similares

Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models
por: Sooreshjani, Moloud Aflaki, et al.
Publicado: (2021)

Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
por: Nikhil, Kumar, et al.
Publicado: (2020)

Molecular Interplay between AURKA and SPOP Dictates CRPC Pathogenesis via Androgen Receptor
por: Nikhil, Kumar, et al.
Publicado: (2020)

The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation
por: Lind, Guro E, et al.
Publicado: (2005)

Antioxidant Treatment Promotes Prostate Epithelial Proliferation in Nkx3.1 Mutant Mice
por: Martinez, Erin E., et al.
Publicado: (2012)

Nkx3.1 controls the DNA repair response in the mouse prostate
por: Zhang, Hailan, et al.
Publicado: (2015)

Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation
por: Le Magnen, Clémentine, et al.
Publicado: (2018)

The Role of Nkx3.1 in Cancers and Stemness
por: Antao, Ainsley Mike, et al.
Publicado: (2021)

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
por: Thangapazham, Rajesh, et al.
Publicado: (2014)

NKX3.1 Expression Contributes to Epithelial–Mesenchymal Transition of Prostate Cancer Cells
por: Saydullaeva, Iroda, et al.
Publicado: (2023)

Concurrent Down-Regulation of PTEN and NKX3.1 Expression in Iranian Patients with Prostate Cancer
por: Nodouzi, Vahideh, et al.
Publicado: (2015)

Aurora Kinase A-YBX1 Synergy Fuels Aggressive Oncogenic Phenotypes and Chemoresistance in Castration-Resistant Prostate Cancer
por: Nikhil, Kumar, et al.
Publicado: (2020)

miR-378b Promotes Differentiation of Keratinocytes through NKX3.1
por: Wang, Xi-liang, et al.
Publicado: (2015)

Expression of NKX3.1, Prostatic Specific Antigen and Prostatic Specific Alkaline Phosphatase in Cytology Specimens of Metastatic Prostatic Carcinoma
por: Wang, Minhua, et al.
Publicado: (2021)

Loss-of-Nkx3.1 Leads to Activation of Discrete Downstream Target Genes during Prostate Tumorigenesis
por: Song, Haengseok, et al.
Publicado: (2009)

MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells
por: Iwata, Tsuyoshi, et al.
Publicado: (2010)

Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function
por: Fang, Qiaojun, et al.
Publicado: (2019)

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation
por: Yang, Chih-Cheng, et al.
Publicado: (2014)

Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation
por: Zhang, Yue, et al.
Publicado: (2018)

Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN
por: Sharma, Pankaj, et al.
Publicado: (2013)

Structural Aspects of LIMK Regulation and Pharmacology
por: Chatterjee, Deep, et al.
Publicado: (2022)

LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration
por: Mao, Rui, et al.
Publicado: (2019)

LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features
por: Villalonga, Elodie, et al.
Publicado: (2023)

ETS Transcription Factors Control Transcription of EZH2 and Epigenetic Silencing of the Tumor Suppressor Gene Nkx3.1 in Prostate Cancer
por: Kunderfranco, Paolo, et al.
Publicado: (2010)

Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice
por: Park, Jin Ju, et al.
Publicado: (2020)

LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target
por: Kang, Xi, et al.
Publicado: (2021)

Genetic Interaction between Tmprss2-ERG Gene Fusion and Nkx3.1-Loss Does Not Enhance Prostate Tumorigenesis in Mouse Models
por: Linn, Douglas E., et al.
Publicado: (2015)

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways
por: Sooreshjani, Moloud Aflaki, et al.
Publicado: (2018)

Castration promotes the browning of the prostate tumor microenvironment
por: Alvarez-Artime, Alejandro, et al.
Publicado: (2023)

Keratinocyte Migration in the Developing Eyelid Requires LIMK2
por: Rice, Dennis S., et al.
Publicado: (2012)

ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation
por: Lorenzoni, Marco, et al.
Publicado: (2022)

Determination of ERG(+), EZH2, NKX3.1, and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer
por: Segura‐Moreno, Yenifer Yamile, et al.
Publicado: (2022)

The Homeodomain Transcription Factor NKX3.1 Modulates Bladder Outlet Obstruction Induced Fibrosis in Mice
por: Patel, Mehul S., et al.
Publicado: (2019)

LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1
por: Malvi, Parmanand, et al.
Publicado: (2020)

LIMK1 Interacts with STK25 to Regulate EMT and Promote the Proliferation and Metastasis of Colorectal Cancer
por: Sun, Xuecheng, et al.
Publicado: (2022)

Sensitivity of HOXB13 as a Diagnostic Immunohistochemical Marker of Prostatic Origin in Prostate Cancer Metastases: Comparison to PSA, Prostein, Androgen Receptor, ERG, NKX3.1, PSAP, and PSMA
por: Kristiansen, Ilka, et al.
Publicado: (2017)

Lessons from LIMK1 enzymology and their impact on inhibitor design
por: Salah, Eidarus, et al.
Publicado: (2019)

Castration for Prostatic Hypertrophy
Publicado: (1899)

TNFα-Mediated Loss of β-Catenin/E-Cadherin Association and Subsequent Increase in Cell Migration Is Partially Restored by NKX3.1 Expression in Prostate Cells
por: Debelec-Butuner, Bilge, et al.
Publicado: (2014)

Natural Product-Based Studies for the Management of Castration-Resistant Prostate Cancer: Computational to Clinical Studies
por: Singla, Rajeev K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a2953pfu1ejd0t91jp078jfv2r