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Th17 Cells in Viral Infections—Friend or Foe?

Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 cells also play a central role in the induction of autoimmune diseases. Recent advances have evaluated Th17 ef...

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Autores principales: Paiva, Iury Amancio, Badolato-Corrêa, Jéssica, Familiar-Macedo, Débora, de-Oliveira-Pinto, Luzia Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151546/
https://www.ncbi.nlm.nih.gov/pubmed/34064728
http://dx.doi.org/10.3390/cells10051159
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author Paiva, Iury Amancio
Badolato-Corrêa, Jéssica
Familiar-Macedo, Débora
de-Oliveira-Pinto, Luzia Maria
author_facet Paiva, Iury Amancio
Badolato-Corrêa, Jéssica
Familiar-Macedo, Débora
de-Oliveira-Pinto, Luzia Maria
author_sort Paiva, Iury Amancio
collection PubMed
description Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 cells also play a central role in the induction of autoimmune diseases. Recent advances have evaluated Th17 effector functions during viral infections, including their critical role in the production and induction of pro-inflammatory cytokines and in the recruitment and activation of other immune cells. Thus, Th17 is involved in the induction both of pathogenicity and immunoprotective mechanisms seen in the host’s immune response against viruses. However, certain Th17 cells can also modulate immune responses, since they can secrete immunosuppressive factors, such as IL-10; these cells are called non-pathogenic Th17 cells. Here, we present a brief review of Th17 cells and highlight their involvement in some virus infections. We cover these notions by highlighting the role of Th17 cells in regulating the protective and pathogenic immune response in the context of viral infections. In addition, we will be describing myocarditis and multiple sclerosis as examples of immune diseases triggered by viral infections, in which we will discuss further the roles of Th17 cells in the induction of tissue damage.
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spelling pubmed-81515462021-05-27 Th17 Cells in Viral Infections—Friend or Foe? Paiva, Iury Amancio Badolato-Corrêa, Jéssica Familiar-Macedo, Débora de-Oliveira-Pinto, Luzia Maria Cells Review Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 cells also play a central role in the induction of autoimmune diseases. Recent advances have evaluated Th17 effector functions during viral infections, including their critical role in the production and induction of pro-inflammatory cytokines and in the recruitment and activation of other immune cells. Thus, Th17 is involved in the induction both of pathogenicity and immunoprotective mechanisms seen in the host’s immune response against viruses. However, certain Th17 cells can also modulate immune responses, since they can secrete immunosuppressive factors, such as IL-10; these cells are called non-pathogenic Th17 cells. Here, we present a brief review of Th17 cells and highlight their involvement in some virus infections. We cover these notions by highlighting the role of Th17 cells in regulating the protective and pathogenic immune response in the context of viral infections. In addition, we will be describing myocarditis and multiple sclerosis as examples of immune diseases triggered by viral infections, in which we will discuss further the roles of Th17 cells in the induction of tissue damage. MDPI 2021-05-11 /pmc/articles/PMC8151546/ /pubmed/34064728 http://dx.doi.org/10.3390/cells10051159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paiva, Iury Amancio
Badolato-Corrêa, Jéssica
Familiar-Macedo, Débora
de-Oliveira-Pinto, Luzia Maria
Th17 Cells in Viral Infections—Friend or Foe?
title Th17 Cells in Viral Infections—Friend or Foe?
title_full Th17 Cells in Viral Infections—Friend or Foe?
title_fullStr Th17 Cells in Viral Infections—Friend or Foe?
title_full_unstemmed Th17 Cells in Viral Infections—Friend or Foe?
title_short Th17 Cells in Viral Infections—Friend or Foe?
title_sort th17 cells in viral infections—friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151546/
https://www.ncbi.nlm.nih.gov/pubmed/34064728
http://dx.doi.org/10.3390/cells10051159
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