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Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/ https://www.ncbi.nlm.nih.gov/pubmed/34067086 http://dx.doi.org/10.3390/v13050853 |
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author | Cruz Melguizo, Sara de la Cruz Conty, María Luisa Carmona Payán, Paola Abascal-Saiz, Alejandra Pintando Recarte, Pilar González Rodríguez, Laura Cuenca Marín, Celia Martínez Varea, Alicia Oreja Cuesta, Ana Belén Rodríguez, Pilar Prats Fernández Buhigas, Irene Rodríguez Gallego, María Victoria Fernández Alonso, Ana María López Pérez, Rocío Broullón Molanes, José Román Encinas Pardilla, María Begoña Ramírez Gómez, Mercedes Gimeno Gimeno, María Joaquina Sánchez Muñoz, Antonio Martínez-Pérez, Oscar |
author_facet | Cruz Melguizo, Sara de la Cruz Conty, María Luisa Carmona Payán, Paola Abascal-Saiz, Alejandra Pintando Recarte, Pilar González Rodríguez, Laura Cuenca Marín, Celia Martínez Varea, Alicia Oreja Cuesta, Ana Belén Rodríguez, Pilar Prats Fernández Buhigas, Irene Rodríguez Gallego, María Victoria Fernández Alonso, Ana María López Pérez, Rocío Broullón Molanes, José Román Encinas Pardilla, María Begoña Ramírez Gómez, Mercedes Gimeno Gimeno, María Joaquina Sánchez Muñoz, Antonio Martínez-Pérez, Oscar |
author_sort | Cruz Melguizo, Sara |
collection | PubMed |
description | Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients’ information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms). |
format | Online Article Text |
id | pubmed-8151603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81516032021-05-27 Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study Cruz Melguizo, Sara de la Cruz Conty, María Luisa Carmona Payán, Paola Abascal-Saiz, Alejandra Pintando Recarte, Pilar González Rodríguez, Laura Cuenca Marín, Celia Martínez Varea, Alicia Oreja Cuesta, Ana Belén Rodríguez, Pilar Prats Fernández Buhigas, Irene Rodríguez Gallego, María Victoria Fernández Alonso, Ana María López Pérez, Rocío Broullón Molanes, José Román Encinas Pardilla, María Begoña Ramírez Gómez, Mercedes Gimeno Gimeno, María Joaquina Sánchez Muñoz, Antonio Martínez-Pérez, Oscar Viruses Article Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients’ information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms). MDPI 2021-05-07 /pmc/articles/PMC8151603/ /pubmed/34067086 http://dx.doi.org/10.3390/v13050853 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cruz Melguizo, Sara de la Cruz Conty, María Luisa Carmona Payán, Paola Abascal-Saiz, Alejandra Pintando Recarte, Pilar González Rodríguez, Laura Cuenca Marín, Celia Martínez Varea, Alicia Oreja Cuesta, Ana Belén Rodríguez, Pilar Prats Fernández Buhigas, Irene Rodríguez Gallego, María Victoria Fernández Alonso, Ana María López Pérez, Rocío Broullón Molanes, José Román Encinas Pardilla, María Begoña Ramírez Gómez, Mercedes Gimeno Gimeno, María Joaquina Sánchez Muñoz, Antonio Martínez-Pérez, Oscar Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title | Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title_full | Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title_fullStr | Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title_full_unstemmed | Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title_short | Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study |
title_sort | pregnancy outcomes and sars-cov-2 infection: the spanish obstetric emergency group study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/ https://www.ncbi.nlm.nih.gov/pubmed/34067086 http://dx.doi.org/10.3390/v13050853 |
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