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Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors...

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Autores principales: Cruz Melguizo, Sara, de la Cruz Conty, María Luisa, Carmona Payán, Paola, Abascal-Saiz, Alejandra, Pintando Recarte, Pilar, González Rodríguez, Laura, Cuenca Marín, Celia, Martínez Varea, Alicia, Oreja Cuesta, Ana Belén, Rodríguez, Pilar Prats, Fernández Buhigas, Irene, Rodríguez Gallego, María Victoria, Fernández Alonso, Ana María, López Pérez, Rocío, Broullón Molanes, José Román, Encinas Pardilla, María Begoña, Ramírez Gómez, Mercedes, Gimeno Gimeno, María Joaquina, Sánchez Muñoz, Antonio, Martínez-Pérez, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/
https://www.ncbi.nlm.nih.gov/pubmed/34067086
http://dx.doi.org/10.3390/v13050853
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author Cruz Melguizo, Sara
de la Cruz Conty, María Luisa
Carmona Payán, Paola
Abascal-Saiz, Alejandra
Pintando Recarte, Pilar
González Rodríguez, Laura
Cuenca Marín, Celia
Martínez Varea, Alicia
Oreja Cuesta, Ana Belén
Rodríguez, Pilar Prats
Fernández Buhigas, Irene
Rodríguez Gallego, María Victoria
Fernández Alonso, Ana María
López Pérez, Rocío
Broullón Molanes, José Román
Encinas Pardilla, María Begoña
Ramírez Gómez, Mercedes
Gimeno Gimeno, María Joaquina
Sánchez Muñoz, Antonio
Martínez-Pérez, Oscar
author_facet Cruz Melguizo, Sara
de la Cruz Conty, María Luisa
Carmona Payán, Paola
Abascal-Saiz, Alejandra
Pintando Recarte, Pilar
González Rodríguez, Laura
Cuenca Marín, Celia
Martínez Varea, Alicia
Oreja Cuesta, Ana Belén
Rodríguez, Pilar Prats
Fernández Buhigas, Irene
Rodríguez Gallego, María Victoria
Fernández Alonso, Ana María
López Pérez, Rocío
Broullón Molanes, José Román
Encinas Pardilla, María Begoña
Ramírez Gómez, Mercedes
Gimeno Gimeno, María Joaquina
Sánchez Muñoz, Antonio
Martínez-Pérez, Oscar
author_sort Cruz Melguizo, Sara
collection PubMed
description Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients’ information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms).
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spelling pubmed-81516032021-05-27 Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study Cruz Melguizo, Sara de la Cruz Conty, María Luisa Carmona Payán, Paola Abascal-Saiz, Alejandra Pintando Recarte, Pilar González Rodríguez, Laura Cuenca Marín, Celia Martínez Varea, Alicia Oreja Cuesta, Ana Belén Rodríguez, Pilar Prats Fernández Buhigas, Irene Rodríguez Gallego, María Victoria Fernández Alonso, Ana María López Pérez, Rocío Broullón Molanes, José Román Encinas Pardilla, María Begoña Ramírez Gómez, Mercedes Gimeno Gimeno, María Joaquina Sánchez Muñoz, Antonio Martínez-Pérez, Oscar Viruses Article Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients’ information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms). MDPI 2021-05-07 /pmc/articles/PMC8151603/ /pubmed/34067086 http://dx.doi.org/10.3390/v13050853 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cruz Melguizo, Sara
de la Cruz Conty, María Luisa
Carmona Payán, Paola
Abascal-Saiz, Alejandra
Pintando Recarte, Pilar
González Rodríguez, Laura
Cuenca Marín, Celia
Martínez Varea, Alicia
Oreja Cuesta, Ana Belén
Rodríguez, Pilar Prats
Fernández Buhigas, Irene
Rodríguez Gallego, María Victoria
Fernández Alonso, Ana María
López Pérez, Rocío
Broullón Molanes, José Román
Encinas Pardilla, María Begoña
Ramírez Gómez, Mercedes
Gimeno Gimeno, María Joaquina
Sánchez Muñoz, Antonio
Martínez-Pérez, Oscar
Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title_full Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title_fullStr Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title_full_unstemmed Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title_short Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study
title_sort pregnancy outcomes and sars-cov-2 infection: the spanish obstetric emergency group study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151603/
https://www.ncbi.nlm.nih.gov/pubmed/34067086
http://dx.doi.org/10.3390/v13050853
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