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The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought con...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151700/ https://www.ncbi.nlm.nih.gov/pubmed/34064929 http://dx.doi.org/10.3390/nu13051608 |
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author | Romijn, Michelle van Tilburg, Luca J. L. Hollanders, Jonneke J. van der Voorn, Bibian de Goede, Paul Dolman, Koert M. Heijboer, Annemieke C. Broekman, Birit F. P. Rotteveel, Joost Finken, Martijn J. J. |
author_facet | Romijn, Michelle van Tilburg, Luca J. L. Hollanders, Jonneke J. van der Voorn, Bibian de Goede, Paul Dolman, Koert M. Heijboer, Annemieke C. Broekman, Birit F. P. Rotteveel, Joost Finken, Martijn J. J. |
author_sort | Romijn, Michelle |
collection | PubMed |
description | Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs. |
format | Online Article Text |
id | pubmed-8151700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81517002021-05-27 The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk Romijn, Michelle van Tilburg, Luca J. L. Hollanders, Jonneke J. van der Voorn, Bibian de Goede, Paul Dolman, Koert M. Heijboer, Annemieke C. Broekman, Birit F. P. Rotteveel, Joost Finken, Martijn J. J. Nutrients Article Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs. MDPI 2021-05-11 /pmc/articles/PMC8151700/ /pubmed/34064929 http://dx.doi.org/10.3390/nu13051608 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Romijn, Michelle van Tilburg, Luca J. L. Hollanders, Jonneke J. van der Voorn, Bibian de Goede, Paul Dolman, Koert M. Heijboer, Annemieke C. Broekman, Birit F. P. Rotteveel, Joost Finken, Martijn J. J. The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title | The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title_full | The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title_fullStr | The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title_full_unstemmed | The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title_short | The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk |
title_sort | association between maternal stress and glucocorticoid rhythmicity in human milk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151700/ https://www.ncbi.nlm.nih.gov/pubmed/34064929 http://dx.doi.org/10.3390/nu13051608 |
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