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The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk

Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought con...

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Autores principales: Romijn, Michelle, van Tilburg, Luca J. L., Hollanders, Jonneke J., van der Voorn, Bibian, de Goede, Paul, Dolman, Koert M., Heijboer, Annemieke C., Broekman, Birit F. P., Rotteveel, Joost, Finken, Martijn J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151700/
https://www.ncbi.nlm.nih.gov/pubmed/34064929
http://dx.doi.org/10.3390/nu13051608
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author Romijn, Michelle
van Tilburg, Luca J. L.
Hollanders, Jonneke J.
van der Voorn, Bibian
de Goede, Paul
Dolman, Koert M.
Heijboer, Annemieke C.
Broekman, Birit F. P.
Rotteveel, Joost
Finken, Martijn J. J.
author_facet Romijn, Michelle
van Tilburg, Luca J. L.
Hollanders, Jonneke J.
van der Voorn, Bibian
de Goede, Paul
Dolman, Koert M.
Heijboer, Annemieke C.
Broekman, Birit F. P.
Rotteveel, Joost
Finken, Martijn J. J.
author_sort Romijn, Michelle
collection PubMed
description Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs.
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spelling pubmed-81517002021-05-27 The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk Romijn, Michelle van Tilburg, Luca J. L. Hollanders, Jonneke J. van der Voorn, Bibian de Goede, Paul Dolman, Koert M. Heijboer, Annemieke C. Broekman, Birit F. P. Rotteveel, Joost Finken, Martijn J. J. Nutrients Article Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs. MDPI 2021-05-11 /pmc/articles/PMC8151700/ /pubmed/34064929 http://dx.doi.org/10.3390/nu13051608 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romijn, Michelle
van Tilburg, Luca J. L.
Hollanders, Jonneke J.
van der Voorn, Bibian
de Goede, Paul
Dolman, Koert M.
Heijboer, Annemieke C.
Broekman, Birit F. P.
Rotteveel, Joost
Finken, Martijn J. J.
The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title_full The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title_fullStr The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title_full_unstemmed The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title_short The Association between Maternal Stress and Glucocorticoid Rhythmicity in Human Milk
title_sort association between maternal stress and glucocorticoid rhythmicity in human milk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151700/
https://www.ncbi.nlm.nih.gov/pubmed/34064929
http://dx.doi.org/10.3390/nu13051608
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