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Enhanced Transdermal Delivery of Bisoprolol Hemifumarate via Combined Effect of Iontophoresis and Chemical Enhancers: Ex Vivo Permeation/In Vivo Pharmacokinetic Studies

Bisoprolol hemifumarate (BH) is an antihypertensive drug that is used as first-line treatment for chronic hypertension and angina pectoris. Our study was performed to enhance the transdermal delivery of BH, a hydrophilic drug active with high molecular weight, through differently prepared hydrogels....

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Detalles Bibliográficos
Autores principales: Teaima, Mahmoud H., Mohamed, Mohamed Azmi Ahmed, Abd El Rehem, Randa Tag, Tayel, Saadia A., El-Nabarawi, Mohamed A., Fouad, Shahinaze A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151755/
https://www.ncbi.nlm.nih.gov/pubmed/34068544
http://dx.doi.org/10.3390/pharmaceutics13050682