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Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs

SIMPLE SUMMARY: An early prediction of Breast Cancer Recurrence (BCR) for patients undergoing neoadjuvant chemotherapy (NACT) could better guide clinicians in the identification of the most suitable combination treatments for individual patient scenarios. We proposed a transfer learning approach to...

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Autores principales: Comes, Maria Colomba, La Forgia, Daniele, Didonna, Vittorio, Fanizzi, Annarita, Giotta, Francesco, Latorre, Agnese, Martinelli, Eugenio, Mencattini, Arianna, Paradiso, Angelo Virgilio, Tamborra, Pasquale, Terenzio, Antonella, Zito, Alfredo, Lorusso, Vito, Massafra, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151784/
https://www.ncbi.nlm.nih.gov/pubmed/34064923
http://dx.doi.org/10.3390/cancers13102298
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author Comes, Maria Colomba
La Forgia, Daniele
Didonna, Vittorio
Fanizzi, Annarita
Giotta, Francesco
Latorre, Agnese
Martinelli, Eugenio
Mencattini, Arianna
Paradiso, Angelo Virgilio
Tamborra, Pasquale
Terenzio, Antonella
Zito, Alfredo
Lorusso, Vito
Massafra, Raffaella
author_facet Comes, Maria Colomba
La Forgia, Daniele
Didonna, Vittorio
Fanizzi, Annarita
Giotta, Francesco
Latorre, Agnese
Martinelli, Eugenio
Mencattini, Arianna
Paradiso, Angelo Virgilio
Tamborra, Pasquale
Terenzio, Antonella
Zito, Alfredo
Lorusso, Vito
Massafra, Raffaella
author_sort Comes, Maria Colomba
collection PubMed
description SIMPLE SUMMARY: An early prediction of Breast Cancer Recurrence (BCR) for patients undergoing neoadjuvant chemotherapy (NACT) could better guide clinicians in the identification of the most suitable combination treatments for individual patient scenarios. We proposed a transfer learning approach to give an early prediction of three-year BCR for patients undergoing NACT, using DCE-MRI exams from I-SPY1 TRIAL and BREAST-MRI-NACT-Pilot public databases. Because no technical expertise is required in the extraction of meaningful features from images, the predictive model qualifies as a user-friendly tool for any medical expert in support of therapeutic choices. Only pre-treatment and early-treatment MRI examinations were analyzed to allow for potential therapy changes at a very early stage of treatment. We tested the strength of the model on an independent test. The best predictive performances (accuracy of 85.2%, sensitivity of 84.6%, and AUC of 0.83) were achieved by combining the extracted features with some clinical factors: age, ER, PgR, HER2+. ABSTRACT: Cancer treatment planning benefits from an accurate early prediction of the treatment efficacy. The goal of this study is to give an early prediction of three-year Breast Cancer Recurrence (BCR) for patients who underwent neoadjuvant chemotherapy. We addressed the task from a new perspective based on transfer learning applied to pre-treatment and early-treatment DCE-MRI scans. Firstly, low-level features were automatically extracted from MR images using a pre-trained Convolutional Neural Network (CNN) architecture without human intervention. Subsequently, the prediction model was built with an optimal subset of CNN features and evaluated on two sets of patients from I-SPY1 TRIAL and BREAST-MRI-NACT-Pilot public databases: a fine-tuning dataset (70 not recurrent and 26 recurrent cases), which was primarily used to find the optimal subset of CNN features, and an independent test (45 not recurrent and 17 recurrent cases), whose patients had not been involved in the feature selection process. The best results were achieved when the optimal CNN features were augmented by four clinical variables (age, ER, PgR, HER2+), reaching an accuracy of 91.7% and 85.2%, a sensitivity of 80.8% and 84.6%, a specificity of 95.7% and 85.4%, and an AUC value of 0.93 and 0.83 on the fine-tuning dataset and the independent test, respectively. Finally, the CNN features extracted from pre-treatment and early-treatment exams were revealed to be strong predictors of BCR.
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spelling pubmed-81517842021-05-27 Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs Comes, Maria Colomba La Forgia, Daniele Didonna, Vittorio Fanizzi, Annarita Giotta, Francesco Latorre, Agnese Martinelli, Eugenio Mencattini, Arianna Paradiso, Angelo Virgilio Tamborra, Pasquale Terenzio, Antonella Zito, Alfredo Lorusso, Vito Massafra, Raffaella Cancers (Basel) Article SIMPLE SUMMARY: An early prediction of Breast Cancer Recurrence (BCR) for patients undergoing neoadjuvant chemotherapy (NACT) could better guide clinicians in the identification of the most suitable combination treatments for individual patient scenarios. We proposed a transfer learning approach to give an early prediction of three-year BCR for patients undergoing NACT, using DCE-MRI exams from I-SPY1 TRIAL and BREAST-MRI-NACT-Pilot public databases. Because no technical expertise is required in the extraction of meaningful features from images, the predictive model qualifies as a user-friendly tool for any medical expert in support of therapeutic choices. Only pre-treatment and early-treatment MRI examinations were analyzed to allow for potential therapy changes at a very early stage of treatment. We tested the strength of the model on an independent test. The best predictive performances (accuracy of 85.2%, sensitivity of 84.6%, and AUC of 0.83) were achieved by combining the extracted features with some clinical factors: age, ER, PgR, HER2+. ABSTRACT: Cancer treatment planning benefits from an accurate early prediction of the treatment efficacy. The goal of this study is to give an early prediction of three-year Breast Cancer Recurrence (BCR) for patients who underwent neoadjuvant chemotherapy. We addressed the task from a new perspective based on transfer learning applied to pre-treatment and early-treatment DCE-MRI scans. Firstly, low-level features were automatically extracted from MR images using a pre-trained Convolutional Neural Network (CNN) architecture without human intervention. Subsequently, the prediction model was built with an optimal subset of CNN features and evaluated on two sets of patients from I-SPY1 TRIAL and BREAST-MRI-NACT-Pilot public databases: a fine-tuning dataset (70 not recurrent and 26 recurrent cases), which was primarily used to find the optimal subset of CNN features, and an independent test (45 not recurrent and 17 recurrent cases), whose patients had not been involved in the feature selection process. The best results were achieved when the optimal CNN features were augmented by four clinical variables (age, ER, PgR, HER2+), reaching an accuracy of 91.7% and 85.2%, a sensitivity of 80.8% and 84.6%, a specificity of 95.7% and 85.4%, and an AUC value of 0.93 and 0.83 on the fine-tuning dataset and the independent test, respectively. Finally, the CNN features extracted from pre-treatment and early-treatment exams were revealed to be strong predictors of BCR. MDPI 2021-05-11 /pmc/articles/PMC8151784/ /pubmed/34064923 http://dx.doi.org/10.3390/cancers13102298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Comes, Maria Colomba
La Forgia, Daniele
Didonna, Vittorio
Fanizzi, Annarita
Giotta, Francesco
Latorre, Agnese
Martinelli, Eugenio
Mencattini, Arianna
Paradiso, Angelo Virgilio
Tamborra, Pasquale
Terenzio, Antonella
Zito, Alfredo
Lorusso, Vito
Massafra, Raffaella
Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title_full Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title_fullStr Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title_full_unstemmed Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title_short Early Prediction of Breast Cancer Recurrence for Patients Treated with Neoadjuvant Chemotherapy: A Transfer Learning Approach on DCE-MRIs
title_sort early prediction of breast cancer recurrence for patients treated with neoadjuvant chemotherapy: a transfer learning approach on dce-mris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151784/
https://www.ncbi.nlm.nih.gov/pubmed/34064923
http://dx.doi.org/10.3390/cancers13102298
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