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Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life

Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydroph...

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Detalles Bibliográficos
Autores principales: Boes, Deborah M., Godoy-Hernandez, Albert, McMillan, Duncan G. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151925/
https://www.ncbi.nlm.nih.gov/pubmed/34066904
http://dx.doi.org/10.3390/membranes11050346
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author Boes, Deborah M.
Godoy-Hernandez, Albert
McMillan, Duncan G. G.
author_facet Boes, Deborah M.
Godoy-Hernandez, Albert
McMillan, Duncan G. G.
author_sort Boes, Deborah M.
collection PubMed
description Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome c, alkaline phosphatase, ecto-5’-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases.
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spelling pubmed-81519252021-05-27 Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life Boes, Deborah M. Godoy-Hernandez, Albert McMillan, Duncan G. G. Membranes (Basel) Review Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome c, alkaline phosphatase, ecto-5’-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases. MDPI 2021-05-08 /pmc/articles/PMC8151925/ /pubmed/34066904 http://dx.doi.org/10.3390/membranes11050346 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boes, Deborah M.
Godoy-Hernandez, Albert
McMillan, Duncan G. G.
Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title_full Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title_fullStr Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title_full_unstemmed Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title_short Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life
title_sort peripheral membrane proteins: promising therapeutic targets across domains of life
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151925/
https://www.ncbi.nlm.nih.gov/pubmed/34066904
http://dx.doi.org/10.3390/membranes11050346
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