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IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL
BACKGROUND: Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (I...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152057/ https://www.ncbi.nlm.nih.gov/pubmed/34034707 http://dx.doi.org/10.1186/s12885-021-08086-y |
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author | Tang, Tianjiao Wang, Jing Zhang, Lidan Cheng, Ying Saleh, Laura Gu, Yanni Zhang, Hongbin |
author_facet | Tang, Tianjiao Wang, Jing Zhang, Lidan Cheng, Ying Saleh, Laura Gu, Yanni Zhang, Hongbin |
author_sort | Tang, Tianjiao |
collection | PubMed |
description | BACKGROUND: Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. METHODS: We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. RESULTS: The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. CONCLUSION: IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08086-y. |
format | Online Article Text |
id | pubmed-8152057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81520572021-05-26 IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL Tang, Tianjiao Wang, Jing Zhang, Lidan Cheng, Ying Saleh, Laura Gu, Yanni Zhang, Hongbin BMC Cancer Research Article BACKGROUND: Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. METHODS: We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. RESULTS: The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. CONCLUSION: IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08086-y. BioMed Central 2021-05-25 /pmc/articles/PMC8152057/ /pubmed/34034707 http://dx.doi.org/10.1186/s12885-021-08086-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Tang, Tianjiao Wang, Jing Zhang, Lidan Cheng, Ying Saleh, Laura Gu, Yanni Zhang, Hongbin IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_full | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_fullStr | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_full_unstemmed | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_short | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_sort | iqgap2 acts as an independent prognostic factor and is related to immunosuppression in dlbcl |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152057/ https://www.ncbi.nlm.nih.gov/pubmed/34034707 http://dx.doi.org/10.1186/s12885-021-08086-y |
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