Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig

We previously designed a Carbopol gel formulation (N-IND/MEN) based on a combination of indomethacin solid nanoparticles (IND-NPs) and l-menthol, and we reported that the N-IND/MEN showed high transdermal penetration. However, the detailed mechanism for transdermal penetration of IND-NPs was not cle...

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Detalles Bibliográficos
Autores principales: Otake, Hiroko, Yamaguchi, Mizuki, Ogata, Fumihiko, Deguchi, Saori, Yamamoto, Naoki, Sasaki, Hiroshi, Kawasaki, Naohito, Nagai, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152063/
https://www.ncbi.nlm.nih.gov/pubmed/34066280
http://dx.doi.org/10.3390/ijms22105137

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