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Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

BACKGROUND: Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer’s disease, AD), mi...

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Autores principales: Ribaldi, Federica, Chicherio, Christian, Altomare, Daniele, Martins, Marta, Tomczyk, Szymon, Jelescu, Ileana, Maturana, Enrique, Scheffler, Max, Haller, Sven, Lövblad, Karl-Olof, Pievani, Michela, Garibotto, Valentina, Kliegel, Matthias, Frisoni, Giovanni B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152092/
https://www.ncbi.nlm.nih.gov/pubmed/34034799
http://dx.doi.org/10.1186/s13195-021-00846-z
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author Ribaldi, Federica
Chicherio, Christian
Altomare, Daniele
Martins, Marta
Tomczyk, Szymon
Jelescu, Ileana
Maturana, Enrique
Scheffler, Max
Haller, Sven
Lövblad, Karl-Olof
Pievani, Michela
Garibotto, Valentina
Kliegel, Matthias
Frisoni, Giovanni B.
author_facet Ribaldi, Federica
Chicherio, Christian
Altomare, Daniele
Martins, Marta
Tomczyk, Szymon
Jelescu, Ileana
Maturana, Enrique
Scheffler, Max
Haller, Sven
Lövblad, Karl-Olof
Pievani, Michela
Garibotto, Valentina
Kliegel, Matthias
Frisoni, Giovanni B.
author_sort Ribaldi, Federica
collection PubMed
description BACKGROUND: Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer’s disease, AD), minor psychiatric conditions, neurological, and/or somatic comorbidities. Even if a theoretical framework has been established, the etiology of SCD remains far from elucidated. Clinical observations recently lead to the hypothesis that individuals with incipient AD may have overestimated metacognitive judgements of their own cognitive performance, while those with psychiatric disorders typically present underestimated metacognitive judgements. Moreover, brain connectivity changes are known correlates of AD and psychiatric conditions and might be used as biomarkers to discriminate SCD individuals of different etiologies. The aim of the COSCODE study is to identify metacognition, connectivity, behavioral, and biomarker profiles associated with different etiologies of SCD. Here we present its rationale and study design. METHODS: COSCODE is an observational, longitudinal (4 years), prospective clinical cohort study involving 120 SCD, and 80 control study participants (40 individuals with no cognitive impairment, and 40 living with mild cognitive impairment - MCI, or dementia due to AD), all of which will undergo diffusion magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) as well as behavioral and biomarker assessments at baseline and after 1 and 2 years. Both hypothesis-driven and data-driven cluster analysis approaches will be used to identify SCD sub-types based on metacognition, connectivity, behavioral, and biomarker features. CONCLUSION: COSCODE will allow defining and interpreting the constellation of signs and symptoms associated with different etiologies of SCD, paving the way to the development of cost-effective risk assessment and prevention protocols.
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spelling pubmed-81520922021-05-26 Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design Ribaldi, Federica Chicherio, Christian Altomare, Daniele Martins, Marta Tomczyk, Szymon Jelescu, Ileana Maturana, Enrique Scheffler, Max Haller, Sven Lövblad, Karl-Olof Pievani, Michela Garibotto, Valentina Kliegel, Matthias Frisoni, Giovanni B. Alzheimers Res Ther Research BACKGROUND: Subjective cognitive decline (SCD) is the subjective perception of a decline in memory and/or other cognitive functions in the absence of objective evidence. Some SCD individuals however may suffer from very early stages of neurodegenerative diseases (such as Alzheimer’s disease, AD), minor psychiatric conditions, neurological, and/or somatic comorbidities. Even if a theoretical framework has been established, the etiology of SCD remains far from elucidated. Clinical observations recently lead to the hypothesis that individuals with incipient AD may have overestimated metacognitive judgements of their own cognitive performance, while those with psychiatric disorders typically present underestimated metacognitive judgements. Moreover, brain connectivity changes are known correlates of AD and psychiatric conditions and might be used as biomarkers to discriminate SCD individuals of different etiologies. The aim of the COSCODE study is to identify metacognition, connectivity, behavioral, and biomarker profiles associated with different etiologies of SCD. Here we present its rationale and study design. METHODS: COSCODE is an observational, longitudinal (4 years), prospective clinical cohort study involving 120 SCD, and 80 control study participants (40 individuals with no cognitive impairment, and 40 living with mild cognitive impairment - MCI, or dementia due to AD), all of which will undergo diffusion magnetic resonance imaging (MRI) and functional magnetic resonance imaging (fMRI) as well as behavioral and biomarker assessments at baseline and after 1 and 2 years. Both hypothesis-driven and data-driven cluster analysis approaches will be used to identify SCD sub-types based on metacognition, connectivity, behavioral, and biomarker features. CONCLUSION: COSCODE will allow defining and interpreting the constellation of signs and symptoms associated with different etiologies of SCD, paving the way to the development of cost-effective risk assessment and prevention protocols. BioMed Central 2021-05-25 /pmc/articles/PMC8152092/ /pubmed/34034799 http://dx.doi.org/10.1186/s13195-021-00846-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ribaldi, Federica
Chicherio, Christian
Altomare, Daniele
Martins, Marta
Tomczyk, Szymon
Jelescu, Ileana
Maturana, Enrique
Scheffler, Max
Haller, Sven
Lövblad, Karl-Olof
Pievani, Michela
Garibotto, Valentina
Kliegel, Matthias
Frisoni, Giovanni B.
Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title_full Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title_fullStr Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title_full_unstemmed Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title_short Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design
title_sort brain connectivity and metacognition in persons with subjective cognitive decline (coscode): rationale and study design
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152092/
https://www.ncbi.nlm.nih.gov/pubmed/34034799
http://dx.doi.org/10.1186/s13195-021-00846-z
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