Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer

BACKGROUND: Pancreatic cancer (PC) is a major cause of cancer death. In an effort to improve treatment strategies and outcomes, DNA damage repair (DDR) pathways have been introduced as a new target in PC and in other cancers, through the exploitation of synthetic lethality. Furthermore, genes involv...

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Detalles Bibliográficos
Autores principales: Rapposelli, Ilario Giovanni, Zampiga, Valentina, Cangini, Ilaria, Arcangeli, Valentina, Ravegnani, Mila, Valgiusti, Martina, Pini, Sara, Tamberi, Stefano, Bartolini, Giulia, Passardi, Alessandro, Martinelli, Giovanni, Calistri, Daniele, Frassineti, Giovanni Luca, Falcini, Fabio, Danesi, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152298/
https://www.ncbi.nlm.nih.gov/pubmed/34034685
http://dx.doi.org/10.1186/s12885-021-08368-5

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