Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactivation, and related plasticity as well as memory deficits in Ts1Cje mice, a DS exper...

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Detalles Bibliográficos
Autores principales: Urbano-Gámez, Jesús David, Casañas, Juan José, Benito, Itziar, Montesinos, María Luz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152312/
https://www.ncbi.nlm.nih.gov/pubmed/34034796
http://dx.doi.org/10.1186/s13041-021-00795-6

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