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Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity

Mutations in the Presenilin genes are the major genetic cause of Alzheimer's disease (AD). Presenilin (PS) is highly expressed in the hippocampus, which is particularly vulnerable in AD. Previous studies of PS function in the hippocampus, however, focused exclusively on excitatory neurons. Whet...

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Detalles Bibliográficos
Autores principales:	Lee, Sang Hun, Bolshakov, Vadim Y., Shen, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152317/ https://www.ncbi.nlm.nih.gov/pubmed/34034776 http://dx.doi.org/10.1186/s13041-021-00796-5

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