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Craniofacial Diseases Caused by Defects in Intracellular Trafficking
Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. S...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152478/ https://www.ncbi.nlm.nih.gov/pubmed/34068038 http://dx.doi.org/10.3390/genes12050726 |
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author | Lu, Chung-Ling Kim, Jinoh |
author_facet | Lu, Chung-Ling Kim, Jinoh |
author_sort | Lu, Chung-Ling |
collection | PubMed |
description | Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. Some of the signaling molecules play a critical role in craniofacial morphogenesis. Not surprisingly, variants in the genes encoding intracellular trafficking machinery can cause craniofacial diseases. Despite the fundamental importance of the trafficking pathways in craniofacial morphogenesis, relatively less emphasis is placed on this topic, thus far. Here, we describe craniofacial diseases caused by lesions in the intracellular trafficking machinery and possible treatment strategies for such diseases. |
format | Online Article Text |
id | pubmed-8152478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81524782021-05-27 Craniofacial Diseases Caused by Defects in Intracellular Trafficking Lu, Chung-Ling Kim, Jinoh Genes (Basel) Review Cells use membrane-bound carriers to transport cargo molecules like membrane proteins and soluble proteins, to their destinations. Many signaling receptors and ligands are synthesized in the endoplasmic reticulum and are transported to their destinations through intracellular trafficking pathways. Some of the signaling molecules play a critical role in craniofacial morphogenesis. Not surprisingly, variants in the genes encoding intracellular trafficking machinery can cause craniofacial diseases. Despite the fundamental importance of the trafficking pathways in craniofacial morphogenesis, relatively less emphasis is placed on this topic, thus far. Here, we describe craniofacial diseases caused by lesions in the intracellular trafficking machinery and possible treatment strategies for such diseases. MDPI 2021-05-13 /pmc/articles/PMC8152478/ /pubmed/34068038 http://dx.doi.org/10.3390/genes12050726 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lu, Chung-Ling Kim, Jinoh Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title | Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title_full | Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title_fullStr | Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title_full_unstemmed | Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title_short | Craniofacial Diseases Caused by Defects in Intracellular Trafficking |
title_sort | craniofacial diseases caused by defects in intracellular trafficking |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152478/ https://www.ncbi.nlm.nih.gov/pubmed/34068038 http://dx.doi.org/10.3390/genes12050726 |
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