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Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study

Lead (Pb) is a naturally occurring, highly toxic metal that has adverse effects on children across a range of exposure levels. Limited screening programs leave many children at risk for chronic low-level lead exposure and there is little understanding of what factors may be used to identify children...

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Autores principales: Dickinson-Copeland, Carmen M., Immergluck, Lilly Cheng, Britez, Maria, Yan, Fengxia, Geng, Ruijin, Edelson, Mike, Kendrick-Allwood, Salathiel R., Kordas, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152486/
https://www.ncbi.nlm.nih.gov/pubmed/34068063
http://dx.doi.org/10.3390/ijerph18105163
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author Dickinson-Copeland, Carmen M.
Immergluck, Lilly Cheng
Britez, Maria
Yan, Fengxia
Geng, Ruijin
Edelson, Mike
Kendrick-Allwood, Salathiel R.
Kordas, Katarzyna
author_facet Dickinson-Copeland, Carmen M.
Immergluck, Lilly Cheng
Britez, Maria
Yan, Fengxia
Geng, Ruijin
Edelson, Mike
Kendrick-Allwood, Salathiel R.
Kordas, Katarzyna
author_sort Dickinson-Copeland, Carmen M.
collection PubMed
description Lead (Pb) is a naturally occurring, highly toxic metal that has adverse effects on children across a range of exposure levels. Limited screening programs leave many children at risk for chronic low-level lead exposure and there is little understanding of what factors may be used to identify children at risk. We characterize the distribution of blood lead levels (BLLs) in children aged 0–72 months and their associations with sociodemographic and area-level variables. Data from the Georgia Department of Public Health’s Healthy Homes for Lead Prevention Program surveillance database was used to describe the distribution of BLLs in children living in the metro Atlanta area from 2010 to 2018. Residential addresses were geocoded, and “Hotspot” analyses were performed to determine if BLLs were spatially clustered. Multilevel regression models were used to identify factors associated with clinical BBLs (≥5 µg/dL) and sub-clinical BLLs (2 to <5 µg/dL). From 2010 to 2018, geographically defined hotspots for both clinical and sub-clinical BLLs diffused from the city-central area of Atlanta into suburban areas. Multilevel regression analysis revealed non-Medicaid insurance, the proportion of renters in a given geographical area, and proportion of individuals with a GED/high school diploma as predictors that distinguish children with BLLs 2 to <5 µg/dL from those with lower (<2 µg/dL) or higher (≥5 µg/dL) BLLs. Over half of the study children had BLLs between 2 and 5 µg/dL, a range that does not currently trigger public health measures but that could result in adverse developmental outcomes if ignored.
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spelling pubmed-81524862021-05-27 Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study Dickinson-Copeland, Carmen M. Immergluck, Lilly Cheng Britez, Maria Yan, Fengxia Geng, Ruijin Edelson, Mike Kendrick-Allwood, Salathiel R. Kordas, Katarzyna Int J Environ Res Public Health Article Lead (Pb) is a naturally occurring, highly toxic metal that has adverse effects on children across a range of exposure levels. Limited screening programs leave many children at risk for chronic low-level lead exposure and there is little understanding of what factors may be used to identify children at risk. We characterize the distribution of blood lead levels (BLLs) in children aged 0–72 months and their associations with sociodemographic and area-level variables. Data from the Georgia Department of Public Health’s Healthy Homes for Lead Prevention Program surveillance database was used to describe the distribution of BLLs in children living in the metro Atlanta area from 2010 to 2018. Residential addresses were geocoded, and “Hotspot” analyses were performed to determine if BLLs were spatially clustered. Multilevel regression models were used to identify factors associated with clinical BBLs (≥5 µg/dL) and sub-clinical BLLs (2 to <5 µg/dL). From 2010 to 2018, geographically defined hotspots for both clinical and sub-clinical BLLs diffused from the city-central area of Atlanta into suburban areas. Multilevel regression analysis revealed non-Medicaid insurance, the proportion of renters in a given geographical area, and proportion of individuals with a GED/high school diploma as predictors that distinguish children with BLLs 2 to <5 µg/dL from those with lower (<2 µg/dL) or higher (≥5 µg/dL) BLLs. Over half of the study children had BLLs between 2 and 5 µg/dL, a range that does not currently trigger public health measures but that could result in adverse developmental outcomes if ignored. MDPI 2021-05-13 /pmc/articles/PMC8152486/ /pubmed/34068063 http://dx.doi.org/10.3390/ijerph18105163 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dickinson-Copeland, Carmen M.
Immergluck, Lilly Cheng
Britez, Maria
Yan, Fengxia
Geng, Ruijin
Edelson, Mike
Kendrick-Allwood, Salathiel R.
Kordas, Katarzyna
Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title_full Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title_fullStr Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title_full_unstemmed Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title_short Increased Risk of Sub-Clinical Blood Lead Levels in the 20-County Metro Atlanta, Georgia Area—A Laboratory Surveillance-Based Study
title_sort increased risk of sub-clinical blood lead levels in the 20-county metro atlanta, georgia area—a laboratory surveillance-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152486/
https://www.ncbi.nlm.nih.gov/pubmed/34068063
http://dx.doi.org/10.3390/ijerph18105163
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