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What Is New in Helicobacter pylori Diagnosis. An Overview

Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The “test-and-treat” strategy is recommended by several guidelines and consensus. The choice of testing method is...

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Autores principales: Dore, Maria Pina, Pes, Giovanni Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152493/
https://www.ncbi.nlm.nih.gov/pubmed/34068062
http://dx.doi.org/10.3390/jcm10102091
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author Dore, Maria Pina
Pes, Giovanni Mario
author_facet Dore, Maria Pina
Pes, Giovanni Mario
author_sort Dore, Maria Pina
collection PubMed
description Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The “test-and-treat” strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Culture is the gold standard to detect H. pylori and, possibly, to perform susceptibility testing, however, it requires upper endoscopy and dedicated labs. Recent advances in molecular biology have provided new strategies in detecting infection and antimicrobial resistance without invasive tests. In this review we attempt to offer a comprehensive panorama on the new diagnostic tools and their potential use in clinical settings, in order to accomplish specific recommendations.
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spelling pubmed-81524932021-05-27 What Is New in Helicobacter pylori Diagnosis. An Overview Dore, Maria Pina Pes, Giovanni Mario J Clin Med Review Helicobacter pylori infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The “test-and-treat” strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Culture is the gold standard to detect H. pylori and, possibly, to perform susceptibility testing, however, it requires upper endoscopy and dedicated labs. Recent advances in molecular biology have provided new strategies in detecting infection and antimicrobial resistance without invasive tests. In this review we attempt to offer a comprehensive panorama on the new diagnostic tools and their potential use in clinical settings, in order to accomplish specific recommendations. MDPI 2021-05-13 /pmc/articles/PMC8152493/ /pubmed/34068062 http://dx.doi.org/10.3390/jcm10102091 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dore, Maria Pina
Pes, Giovanni Mario
What Is New in Helicobacter pylori Diagnosis. An Overview
title What Is New in Helicobacter pylori Diagnosis. An Overview
title_full What Is New in Helicobacter pylori Diagnosis. An Overview
title_fullStr What Is New in Helicobacter pylori Diagnosis. An Overview
title_full_unstemmed What Is New in Helicobacter pylori Diagnosis. An Overview
title_short What Is New in Helicobacter pylori Diagnosis. An Overview
title_sort what is new in helicobacter pylori diagnosis. an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152493/
https://www.ncbi.nlm.nih.gov/pubmed/34068062
http://dx.doi.org/10.3390/jcm10102091
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