Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp(2)-iminosugar fragment

The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their potential use as anticancer vaccines. Herein, the conformational preferenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Bermejo, Iris A., Navo, Claudio D., Castro-López, Jorge, Guerreiro, Ana, Jiménez-Moreno, Ester, Sánchez Fernández, Elena M., García-Martín, Fayna, Hinou, Hiroshi, Nishimura, Shin-Ichiro, García Fernández, José M., Mellet, Carmen Ortiz, Avenoza, Alberto, Busto, Jesús H., Bernardes, Gonçalo J. L., Hurtado-Guerrero, Ramón, Peregrina, Jesús M., Corzana, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152572/
https://www.ncbi.nlm.nih.gov/pubmed/34122869
http://dx.doi.org/10.1039/c9sc06334j

Ejemplares similares

Ejemplares similares