Phospholipase iPLA(2)β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to accumulation of 15-hydroperoxy-arachidonoyl-PE (15-HpETE-PE) generated by complexes of 15-lipoxygenase (15-LOX) and a scaffold protein, PEBP1. As Ca(2+)-independent phospholipase PLA(2) (iPLA(2)β, PLA2G6/PNPLA9 gene), can...

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Detalles Bibliográficos
Autores principales: Sun, Wan-Yang, Tyurin, Vladimir A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Anthonymuthu, Tamil S., Zhai, Yu-Jia, Pan, Ming-Hai, Gong, Hai-Biao, Lu, Dan-Hua, Sun, Jie, Duan, Wen-Jun, Korolev, Sergey, Abramov, Andrey Y., Angelova, Plamena R., Miller, Ian, Beharier, Ofer, Mao, Gao-Wei, Dar, Haider H., Kapralov, Alexandr A., Amoscato, Andrew A., Hastings, Teresa G., Greenamyre, J. Timothy, Chu, Charleen T., Sadovsky, Yoel, Bahar, Ivet, Bayır, Hülya, Tyurina, Yulia Y., He, Rong-Rong, Kagan, Valerian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152680/
https://www.ncbi.nlm.nih.gov/pubmed/33542532
http://dx.doi.org/10.1038/s41589-020-00734-x

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