Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers

Hit finding in early drug discovery is often based on high throughput screening (HTS) of existing and historical compound libraries, which can limit chemical diversity, is time-consuming, very costly, and environmentally not sustainable. On-the-fly compound synthesis and in situ screening in a highl...

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Detalles Bibliográficos
Autores principales: Gao, Kai, Shaabani, Shabnam, Xu, Ruixue, Zarganes-Tzitzikas, Tryfon, Gao, Li, Ahmadianmoghaddam, Maryam, Groves, Matthew R., Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152715/
https://www.ncbi.nlm.nih.gov/pubmed/34124680
http://dx.doi.org/10.1039/d1md00087j

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