Cargando…

Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments

The addition of Dual Rinse HEDP, an etidronate powder, to a sodium hypochlorite (NaOCl) solution can create a combined single endodontic irrigant with a soft tissue-dissolving and a decalcifying effect, which can replace traditional alternating irrigation with chemically non-compatible solutions. Wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Ballal, Nidambur Vasudev, Ivica, Anja, Meneses, Pamela, Narkedamalli, Raj Kumar, Attin, Thomas, Zehnder, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152752/
https://www.ncbi.nlm.nih.gov/pubmed/34068094
http://dx.doi.org/10.3390/ma14102531
_version_ 1783698661296832512
author Ballal, Nidambur Vasudev
Ivica, Anja
Meneses, Pamela
Narkedamalli, Raj Kumar
Attin, Thomas
Zehnder, Matthias
author_facet Ballal, Nidambur Vasudev
Ivica, Anja
Meneses, Pamela
Narkedamalli, Raj Kumar
Attin, Thomas
Zehnder, Matthias
author_sort Ballal, Nidambur Vasudev
collection PubMed
description The addition of Dual Rinse HEDP, an etidronate powder, to a sodium hypochlorite (NaOCl) solution can create a combined single endodontic irrigant with a soft tissue-dissolving and a decalcifying effect, which can replace traditional alternating irrigation with chemically non-compatible solutions. While the short-term compatibility between NaOCl and 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) has been shown, it remains unclear whether ultrasonic activation of a combined NaOCl & HEDP solution immediately reduces the available chlorine and/or renders the NaOCl ineffective in dissolving organic tissue remnants. This was tested in three experiments: (1) direct activation in test tubes in an ultrasonic bath and then the activation by an ultrasonically oscillating tip (IrriSafe) in (2) an epoxy resin model containing a simulated isthmus filled with gelatin, and (3) extracted teeth with simulated resorption cavities filled with soft tissue. The control solutions were physiological saline and 2.5% NaOCl without HEDP. In (1), available chlorine after 30 s of ultrasonic activation (37 kHz) of test and control solution was assessed, as well as shrimp tissue weight loss in direct exposure. In (2) and (3), the ultrasonic tip was driven at 1/3 of full power using the respective unit, and areas of removed gelatin from the isthmus and tissue weight loss were used as the outcomes, respectively. Experiment (1) revealed no negative impact by HEDP on available chlorine (1), while all three experiments showed a highly significant (p > 0.001) synergistic effect, which was not hampered by HEDP, between NaOCl and ultrasonic activation regarding tissue weight loss (1, 3) and dissolution of gelatin (2).
format Online
Article
Text
id pubmed-8152752
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81527522021-05-27 Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments Ballal, Nidambur Vasudev Ivica, Anja Meneses, Pamela Narkedamalli, Raj Kumar Attin, Thomas Zehnder, Matthias Materials (Basel) Article The addition of Dual Rinse HEDP, an etidronate powder, to a sodium hypochlorite (NaOCl) solution can create a combined single endodontic irrigant with a soft tissue-dissolving and a decalcifying effect, which can replace traditional alternating irrigation with chemically non-compatible solutions. While the short-term compatibility between NaOCl and 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) has been shown, it remains unclear whether ultrasonic activation of a combined NaOCl & HEDP solution immediately reduces the available chlorine and/or renders the NaOCl ineffective in dissolving organic tissue remnants. This was tested in three experiments: (1) direct activation in test tubes in an ultrasonic bath and then the activation by an ultrasonically oscillating tip (IrriSafe) in (2) an epoxy resin model containing a simulated isthmus filled with gelatin, and (3) extracted teeth with simulated resorption cavities filled with soft tissue. The control solutions were physiological saline and 2.5% NaOCl without HEDP. In (1), available chlorine after 30 s of ultrasonic activation (37 kHz) of test and control solution was assessed, as well as shrimp tissue weight loss in direct exposure. In (2) and (3), the ultrasonic tip was driven at 1/3 of full power using the respective unit, and areas of removed gelatin from the isthmus and tissue weight loss were used as the outcomes, respectively. Experiment (1) revealed no negative impact by HEDP on available chlorine (1), while all three experiments showed a highly significant (p > 0.001) synergistic effect, which was not hampered by HEDP, between NaOCl and ultrasonic activation regarding tissue weight loss (1, 3) and dissolution of gelatin (2). MDPI 2021-05-13 /pmc/articles/PMC8152752/ /pubmed/34068094 http://dx.doi.org/10.3390/ma14102531 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ballal, Nidambur Vasudev
Ivica, Anja
Meneses, Pamela
Narkedamalli, Raj Kumar
Attin, Thomas
Zehnder, Matthias
Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title_full Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title_fullStr Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title_full_unstemmed Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title_short Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments
title_sort influence of 1-hydroxyethylidene-1,1-diphosphonic acid on the soft tissue-dissolving and gelatinolytic effect of ultrasonically activated sodium hypochlorite in simulated endodontic environments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152752/
https://www.ncbi.nlm.nih.gov/pubmed/34068094
http://dx.doi.org/10.3390/ma14102531
work_keys_str_mv AT ballalnidamburvasudev influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments
AT ivicaanja influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments
AT menesespamela influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments
AT narkedamallirajkumar influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments
AT attinthomas influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments
AT zehndermatthias influenceof1hydroxyethylidene11diphosphonicacidonthesofttissuedissolvingandgelatinolyticeffectofultrasonicallyactivatedsodiumhypochloriteinsimulatedendodonticenvironments