The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies

The conceptual technology of small molecule glycomimetics, exemplified by compounds C1–4, has shown promising protective effects against lipid-induced endothelial dysfunction, restorative effects on diabetic endothelial colony forming cells, and preventative effects on downstream vascular calcificat...

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Detalles Bibliográficos
Autores principales: Gill, Daniel M., R. Povinelli, Ana Paula, Zazeri, Gabriel, Shamir, Sabrina A., Mahmoud, Ayman M., Wilkinson, Fiona L., Alexander, M. Yvonne, L. Cornelio, Marinonio, Jones, Alan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152814/
https://www.ncbi.nlm.nih.gov/pubmed/34124676
http://dx.doi.org/10.1039/d0md00366b

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