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Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local applicati...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152983/ https://www.ncbi.nlm.nih.gov/pubmed/34068191 http://dx.doi.org/10.3390/nu13051643 |
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author | Friščić, Jasna Dürholz, Kerstin Chen, Xi Engdahl, Cecilia Möller, Lisa Schett, Georg Zaiss, Mario M. Hoffmann, Markus H. |
author_facet | Friščić, Jasna Dürholz, Kerstin Chen, Xi Engdahl, Cecilia Möller, Lisa Schett, Georg Zaiss, Mario M. Hoffmann, Markus H. |
author_sort | Friščić, Jasna |
collection | PubMed |
description | Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function. |
format | Online Article Text |
id | pubmed-8152983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81529832021-05-27 Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming Friščić, Jasna Dürholz, Kerstin Chen, Xi Engdahl, Cecilia Möller, Lisa Schett, Georg Zaiss, Mario M. Hoffmann, Markus H. Nutrients Communication Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function. MDPI 2021-05-13 /pmc/articles/PMC8152983/ /pubmed/34068191 http://dx.doi.org/10.3390/nu13051643 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Friščić, Jasna Dürholz, Kerstin Chen, Xi Engdahl, Cecilia Möller, Lisa Schett, Georg Zaiss, Mario M. Hoffmann, Markus H. Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title | Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title_full | Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title_fullStr | Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title_full_unstemmed | Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title_short | Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming |
title_sort | dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152983/ https://www.ncbi.nlm.nih.gov/pubmed/34068191 http://dx.doi.org/10.3390/nu13051643 |
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