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Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming

Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local applicati...

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Autores principales: Friščić, Jasna, Dürholz, Kerstin, Chen, Xi, Engdahl, Cecilia, Möller, Lisa, Schett, Georg, Zaiss, Mario M., Hoffmann, Markus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152983/
https://www.ncbi.nlm.nih.gov/pubmed/34068191
http://dx.doi.org/10.3390/nu13051643
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author Friščić, Jasna
Dürholz, Kerstin
Chen, Xi
Engdahl, Cecilia
Möller, Lisa
Schett, Georg
Zaiss, Mario M.
Hoffmann, Markus H.
author_facet Friščić, Jasna
Dürholz, Kerstin
Chen, Xi
Engdahl, Cecilia
Möller, Lisa
Schett, Georg
Zaiss, Mario M.
Hoffmann, Markus H.
author_sort Friščić, Jasna
collection PubMed
description Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function.
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spelling pubmed-81529832021-05-27 Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming Friščić, Jasna Dürholz, Kerstin Chen, Xi Engdahl, Cecilia Möller, Lisa Schett, Georg Zaiss, Mario M. Hoffmann, Markus H. Nutrients Communication Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence on inflammation driven by innate immunity remains understudied. Here, we show that propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated by synovial fibroblasts. On a cellular level, incubation of synovial fibroblasts with propionate or a physiological mixture of short-chain fatty acids interfered with production of inflammatory mediators and migration and induced immune-regulatory fibroblast senescence. Our study suggests that propionate mediates its alleviating effect on arthritis by direct abrogation of local arthritogenic fibroblast function. MDPI 2021-05-13 /pmc/articles/PMC8152983/ /pubmed/34068191 http://dx.doi.org/10.3390/nu13051643 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Friščić, Jasna
Dürholz, Kerstin
Chen, Xi
Engdahl, Cecilia
Möller, Lisa
Schett, Georg
Zaiss, Mario M.
Hoffmann, Markus H.
Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title_full Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title_fullStr Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title_full_unstemmed Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title_short Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming
title_sort dietary derived propionate regulates pathogenic fibroblast function and ameliorates experimental arthritis and inflammatory tissue priming
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152983/
https://www.ncbi.nlm.nih.gov/pubmed/34068191
http://dx.doi.org/10.3390/nu13051643
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