Cargando…

Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study

Among hemodialysis patients aged more than 40 years old, previous large-scale studies showed statin treatment had no effect on reducing cardiovascular adverse events. However, young-adult-onset end-stage renal disease (ESRD) patients have different physicosocial factors compared to older ESRD patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Ya-Lien, Yang, Huang-Yu, Wu, Chao-Yi, Tsai, Chung-Ying, Chen, Chao-Yu, Hsiao, Ching-Chung, Hsu, Hsiang-Hao, Tian, Ya-Chung, Yen, Chieh-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152985/
https://www.ncbi.nlm.nih.gov/pubmed/34068144
http://dx.doi.org/10.3390/jcm10102097
_version_ 1783698703226241024
author Cheng, Ya-Lien
Yang, Huang-Yu
Wu, Chao-Yi
Tsai, Chung-Ying
Chen, Chao-Yu
Hsiao, Ching-Chung
Hsu, Hsiang-Hao
Tian, Ya-Chung
Yen, Chieh-Li
author_facet Cheng, Ya-Lien
Yang, Huang-Yu
Wu, Chao-Yi
Tsai, Chung-Ying
Chen, Chao-Yu
Hsiao, Ching-Chung
Hsu, Hsiang-Hao
Tian, Ya-Chung
Yen, Chieh-Li
author_sort Cheng, Ya-Lien
collection PubMed
description Among hemodialysis patients aged more than 40 years old, previous large-scale studies showed statin treatment had no effect on reducing cardiovascular adverse events. However, young-adult-onset end-stage renal disease (ESRD) patients have different physicosocial factors compared to older ESRD patients. The benefit of statins in such a specific group has not been well evaluated. Through the use of Taiwan’s National Health Insurance Research Database (NHIRD), young adult patients aged 20–40 with incident ESRD requiring permanent dialysis between 1 January 2003 and 31 December 2015 were identified. The enrollees were further divided into two groups depending on whether they received statin therapy for more than 90 days (statin group) or never received any statin (nonstatin group) in the first year after initiation of dialysis. Propensity score weighting (PSW) was used to balance the baseline characteristics between the two groups. After PSW, the statin group (n = 771) exhibited a higher rate of major adverse cardiac and cerebrovascular events (MACCEs) (2.65% vs. 1.44%, hazard ratio (HR): 1.87, 95% confidence interval (CI): 1.43–2.45), and acute myocardial infarction (1.51% vs. 0.30%, HR: 5.34, 95% CI: 3.40–8.39) compared to the nonstatin group (n = 1709). The risk of all-cause mortality, cardiovascular (CV) death. and stroke did not significantly differ between the two groups. Similar to older patients, this study demonstrated that statin therapy cannot offer any protective effects in reducing CV outcomes among young adult ESRD patients undergoing dialysis.
format Online
Article
Text
id pubmed-8152985
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81529852021-05-27 Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study Cheng, Ya-Lien Yang, Huang-Yu Wu, Chao-Yi Tsai, Chung-Ying Chen, Chao-Yu Hsiao, Ching-Chung Hsu, Hsiang-Hao Tian, Ya-Chung Yen, Chieh-Li J Clin Med Article Among hemodialysis patients aged more than 40 years old, previous large-scale studies showed statin treatment had no effect on reducing cardiovascular adverse events. However, young-adult-onset end-stage renal disease (ESRD) patients have different physicosocial factors compared to older ESRD patients. The benefit of statins in such a specific group has not been well evaluated. Through the use of Taiwan’s National Health Insurance Research Database (NHIRD), young adult patients aged 20–40 with incident ESRD requiring permanent dialysis between 1 January 2003 and 31 December 2015 were identified. The enrollees were further divided into two groups depending on whether they received statin therapy for more than 90 days (statin group) or never received any statin (nonstatin group) in the first year after initiation of dialysis. Propensity score weighting (PSW) was used to balance the baseline characteristics between the two groups. After PSW, the statin group (n = 771) exhibited a higher rate of major adverse cardiac and cerebrovascular events (MACCEs) (2.65% vs. 1.44%, hazard ratio (HR): 1.87, 95% confidence interval (CI): 1.43–2.45), and acute myocardial infarction (1.51% vs. 0.30%, HR: 5.34, 95% CI: 3.40–8.39) compared to the nonstatin group (n = 1709). The risk of all-cause mortality, cardiovascular (CV) death. and stroke did not significantly differ between the two groups. Similar to older patients, this study demonstrated that statin therapy cannot offer any protective effects in reducing CV outcomes among young adult ESRD patients undergoing dialysis. MDPI 2021-05-13 /pmc/articles/PMC8152985/ /pubmed/34068144 http://dx.doi.org/10.3390/jcm10102097 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Ya-Lien
Yang, Huang-Yu
Wu, Chao-Yi
Tsai, Chung-Ying
Chen, Chao-Yu
Hsiao, Ching-Chung
Hsu, Hsiang-Hao
Tian, Ya-Chung
Yen, Chieh-Li
Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title_full Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title_fullStr Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title_full_unstemmed Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title_short Does Statin Therapy Reduce the Risks of Mortality and Major Adverse Cardiac and Cerebrovascular Events in Young Adults with End-Stage Renal Disease? Population-Based Cohort Study
title_sort does statin therapy reduce the risks of mortality and major adverse cardiac and cerebrovascular events in young adults with end-stage renal disease? population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152985/
https://www.ncbi.nlm.nih.gov/pubmed/34068144
http://dx.doi.org/10.3390/jcm10102097
work_keys_str_mv AT chengyalien doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT yanghuangyu doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT wuchaoyi doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT tsaichungying doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT chenchaoyu doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT hsiaochingchung doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT hsuhsianghao doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT tianyachung doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy
AT yenchiehli doesstatintherapyreducetherisksofmortalityandmajoradversecardiacandcerebrovasculareventsinyoungadultswithendstagerenaldiseasepopulationbasedcohortstudy