A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons

Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly to any event in the brain under normal or pathological con...

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Autores principales: Bartholome, Odile, de la Brassinne Bonardeaux, Orianne, Neirinckx, Virginie, Rogister, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Feature Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153048/
https://www.ncbi.nlm.nih.gov/pubmed/34296100
http://dx.doi.org/10.1093/texcom/tgaa026
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author Bartholome, Odile
de la Brassinne Bonardeaux, Orianne
Neirinckx, Virginie
Rogister, Bernard
author_facet Bartholome, Odile
de la Brassinne Bonardeaux, Orianne
Neirinckx, Virginie
Rogister, Bernard
author_sort Bartholome, Odile
collection PubMed
description Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly to any event in the brain under normal or pathological conditions. In this review, we will summarize the current knowledge about the fundamentals of fast-spiking parvalbumin-positive neurons, focusing on their morphology and specific channel/protein content. Next, we will explore their development, maturation, and migration in the brain. Finally, we will unravel their potential contribution to the physiopathology of epilepsy.
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spelling pubmed-81530482021-07-21 A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons Bartholome, Odile de la Brassinne Bonardeaux, Orianne Neirinckx, Virginie Rogister, Bernard Cereb Cortex Commun Feature Article Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly to any event in the brain under normal or pathological conditions. In this review, we will summarize the current knowledge about the fundamentals of fast-spiking parvalbumin-positive neurons, focusing on their morphology and specific channel/protein content. Next, we will explore their development, maturation, and migration in the brain. Finally, we will unravel their potential contribution to the physiopathology of epilepsy. Oxford University Press 2020-06-19 /pmc/articles/PMC8153048/ /pubmed/34296100 http://dx.doi.org/10.1093/texcom/tgaa026 Text en © The Author(s) 2020. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Feature Article
Bartholome, Odile
de la Brassinne Bonardeaux, Orianne
Neirinckx, Virginie
Rogister, Bernard
A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title_full A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title_fullStr A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title_full_unstemmed A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title_short A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
title_sort composite sketch of fast-spiking parvalbumin-positive neurons
topic Feature Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153048/
https://www.ncbi.nlm.nih.gov/pubmed/34296100
http://dx.doi.org/10.1093/texcom/tgaa026
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