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Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions

The 2D wavelet transform modulus maxima (WTMM) method is used to perform a comparison of the spatial fluctuations of mammographic breast tissue from patients with invasive lobular carcinoma, those with invasive ductal carcinoma, and those with benign lesions. We follow a procedure developed and vali...

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Autores principales: Gerasimova-Chechkina, Evgeniya, Toner, Brian C., Batchelder, Kendra A., White, Basel, Freynd, Genrietta, Antipev, Igor, Arneodo, Alain, Khalil, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153084/
https://www.ncbi.nlm.nih.gov/pubmed/34054577
http://dx.doi.org/10.3389/fphys.2021.660883
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author Gerasimova-Chechkina, Evgeniya
Toner, Brian C.
Batchelder, Kendra A.
White, Basel
Freynd, Genrietta
Antipev, Igor
Arneodo, Alain
Khalil, Andre
author_facet Gerasimova-Chechkina, Evgeniya
Toner, Brian C.
Batchelder, Kendra A.
White, Basel
Freynd, Genrietta
Antipev, Igor
Arneodo, Alain
Khalil, Andre
author_sort Gerasimova-Chechkina, Evgeniya
collection PubMed
description The 2D wavelet transform modulus maxima (WTMM) method is used to perform a comparison of the spatial fluctuations of mammographic breast tissue from patients with invasive lobular carcinoma, those with invasive ductal carcinoma, and those with benign lesions. We follow a procedure developed and validated in a previous study, in which a sliding window protocol is used to analyze thousands of small subregions in a given mammogram. These subregions are categorized according to their Hurst exponent values (H): fatty tissue (H ≤ 0.45), dense tissue (H ≥ 0.55), and disrupted tissue potentially linked with tumor-associated loss of homeostasis (0.45 < H < 0.55). Following this categorization scheme, we compare the mammographic tissue composition of the breasts. First, we show that cancerous breasts are significantly different than breasts with a benign lesion (p-value ∼ 0.002). Second, the asymmetry between a patient’s cancerous breast and its contralateral counterpart, when compared to the asymmetry from patients with benign lesions, is also statistically significant (p-value ∼ 0.006). And finally, we show that lobular and ductal cancerous breasts show similar levels of disruption and similar levels of asymmetry. This study demonstrates reproducibility of the WTMM sliding-window approach to help detect and characterize tumor-associated breast tissue disruption from standard mammography. It also shows promise to help with the detection lobular lesions that typically go undetected via standard screening mammography at a much higher rate than ductal lesions. Here both types are assessed similarly.
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spelling pubmed-81530842021-05-27 Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions Gerasimova-Chechkina, Evgeniya Toner, Brian C. Batchelder, Kendra A. White, Basel Freynd, Genrietta Antipev, Igor Arneodo, Alain Khalil, Andre Front Physiol Physiology The 2D wavelet transform modulus maxima (WTMM) method is used to perform a comparison of the spatial fluctuations of mammographic breast tissue from patients with invasive lobular carcinoma, those with invasive ductal carcinoma, and those with benign lesions. We follow a procedure developed and validated in a previous study, in which a sliding window protocol is used to analyze thousands of small subregions in a given mammogram. These subregions are categorized according to their Hurst exponent values (H): fatty tissue (H ≤ 0.45), dense tissue (H ≥ 0.55), and disrupted tissue potentially linked with tumor-associated loss of homeostasis (0.45 < H < 0.55). Following this categorization scheme, we compare the mammographic tissue composition of the breasts. First, we show that cancerous breasts are significantly different than breasts with a benign lesion (p-value ∼ 0.002). Second, the asymmetry between a patient’s cancerous breast and its contralateral counterpart, when compared to the asymmetry from patients with benign lesions, is also statistically significant (p-value ∼ 0.006). And finally, we show that lobular and ductal cancerous breasts show similar levels of disruption and similar levels of asymmetry. This study demonstrates reproducibility of the WTMM sliding-window approach to help detect and characterize tumor-associated breast tissue disruption from standard mammography. It also shows promise to help with the detection lobular lesions that typically go undetected via standard screening mammography at a much higher rate than ductal lesions. Here both types are assessed similarly. Frontiers Media S.A. 2021-05-05 /pmc/articles/PMC8153084/ /pubmed/34054577 http://dx.doi.org/10.3389/fphys.2021.660883 Text en Copyright © 2021 Gerasimova-Chechkina, Toner, Batchelder, White, Freynd, Antipev, Arneodo and Khalil. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Gerasimova-Chechkina, Evgeniya
Toner, Brian C.
Batchelder, Kendra A.
White, Basel
Freynd, Genrietta
Antipev, Igor
Arneodo, Alain
Khalil, Andre
Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title_full Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title_fullStr Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title_full_unstemmed Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title_short Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions
title_sort loss of mammographic tissue homeostasis in invasive lobular and ductal breast carcinomas vs. benign lesions
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153084/
https://www.ncbi.nlm.nih.gov/pubmed/34054577
http://dx.doi.org/10.3389/fphys.2021.660883
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