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Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also...

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Autores principales: Biosca-Brull, Judit, Pérez-Fernández, Cristian, Mora, Santiago, Carrillo, Beatriz, Pinos, Helena, Conejo, Nelida Maria, Collado, Paloma, Arias, Jorge L., Martín-Sánchez, Fernando, Sánchez-Santed, Fernando, Colomina, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153127/
https://www.ncbi.nlm.nih.gov/pubmed/34068255
http://dx.doi.org/10.3390/ijerph18105190
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author Biosca-Brull, Judit
Pérez-Fernández, Cristian
Mora, Santiago
Carrillo, Beatriz
Pinos, Helena
Conejo, Nelida Maria
Collado, Paloma
Arias, Jorge L.
Martín-Sánchez, Fernando
Sánchez-Santed, Fernando
Colomina, Maria Teresa
author_facet Biosca-Brull, Judit
Pérez-Fernández, Cristian
Mora, Santiago
Carrillo, Beatriz
Pinos, Helena
Conejo, Nelida Maria
Collado, Paloma
Arias, Jorge L.
Martín-Sánchez, Fernando
Sánchez-Santed, Fernando
Colomina, Maria Teresa
author_sort Biosca-Brull, Judit
collection PubMed
description Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
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spelling pubmed-81531272021-05-27 Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models Biosca-Brull, Judit Pérez-Fernández, Cristian Mora, Santiago Carrillo, Beatriz Pinos, Helena Conejo, Nelida Maria Collado, Paloma Arias, Jorge L. Martín-Sánchez, Fernando Sánchez-Santed, Fernando Colomina, Maria Teresa Int J Environ Res Public Health Review Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies. MDPI 2021-05-13 /pmc/articles/PMC8153127/ /pubmed/34068255 http://dx.doi.org/10.3390/ijerph18105190 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Biosca-Brull, Judit
Pérez-Fernández, Cristian
Mora, Santiago
Carrillo, Beatriz
Pinos, Helena
Conejo, Nelida Maria
Collado, Paloma
Arias, Jorge L.
Martín-Sánchez, Fernando
Sánchez-Santed, Fernando
Colomina, Maria Teresa
Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title_full Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title_fullStr Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title_full_unstemmed Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title_short Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
title_sort relationship between autism spectrum disorder and pesticides: a systematic review of human and preclinical models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153127/
https://www.ncbi.nlm.nih.gov/pubmed/34068255
http://dx.doi.org/10.3390/ijerph18105190
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