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The Combination of Single-Cell and Next-Generation Sequencing Can Reveal Mosaicism for BRCA2 Mutations and the Fine Molecular Details of Tumorigenesis

SIMPLE SUMMARY: Germline and somatic BRCA1/2 mutations may define therapeutic targets and refine cancer treatment options. However, routine BRCA diagnostic approaches cannot reveal the exact time and origin of BRCA1/2 mutation formation, and thus, the fine details of their contribution to tumor prog...

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Detalles Bibliográficos
Autores principales:	Gráf, Alexandra, Enyedi, Márton Zsolt, Pintér, Lajos, Kriston-Pál, Éva, Jaksa, Gábor, Bálind, Árpád, Ezer, Éva, Horváth, Péter, Sükösd, Farkas, Kiss, Ernő, Haracska, Lajos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153129/ https://www.ncbi.nlm.nih.gov/pubmed/34068254 http://dx.doi.org/10.3390/cancers13102354

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