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Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release

Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the...

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Autores principales: Gonçalves, José L. M., Lopes, Ana Beatriz C., Baleizão, Carlos, Farinha, José Paulo S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153141/
https://www.ncbi.nlm.nih.gov/pubmed/34068257
http://dx.doi.org/10.3390/pharmaceutics13050716
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author Gonçalves, José L. M.
Lopes, Ana Beatriz C.
Baleizão, Carlos
Farinha, José Paulo S.
author_facet Gonçalves, José L. M.
Lopes, Ana Beatriz C.
Baleizão, Carlos
Farinha, José Paulo S.
author_sort Gonçalves, José L. M.
collection PubMed
description Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the system was optimized by a novel approach using selective functionalization of the silica pores to tune the carrier-cargo interaction and by tunning the amount of grafted polymer. The system features excellent retention of cationic cargo at low pH and a burst release at higher pH. This results from the expanded-collapsed conformation transition of the pH-responsive polymer shell and the simultaneous change in the interaction between the cargo and the polymer shell and the modified pore walls. At low pH, the electrostatic interaction of the cationic cargo with the protonated amine groups of the extended polymer shell retains the cargo, resulting in very low leakage (OFF state). At high pH, the electrostatic interaction with the cargo is lost (due to deprotonation of the polymer amine groups), and the polymer shell collapses, squeezing out the cargo in a burst release (ON state). Pore functionalization in combination with the stimuli-responsive polymer shell is a very promising strategy to design high-performance ON:OFF smart hybrid nanocarriers for stimuli-actuated cargo release, with great potential for application in the controlled release of drugs and other biologically active agents.
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spelling pubmed-81531412021-05-27 Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release Gonçalves, José L. M. Lopes, Ana Beatriz C. Baleizão, Carlos Farinha, José Paulo S. Pharmaceutics Article Highly efficient pH-modulated cargo release was achieved with a new hybrid nanocarrier composed of a mesoporous silica core with functionalized pores and a grafted pH-responsive crosslinked polymer shell of 2-(diisopropylamino)ethyl methacrylate (pKa ≈ 6.5). The retention/release performance of the system was optimized by a novel approach using selective functionalization of the silica pores to tune the carrier-cargo interaction and by tunning the amount of grafted polymer. The system features excellent retention of cationic cargo at low pH and a burst release at higher pH. This results from the expanded-collapsed conformation transition of the pH-responsive polymer shell and the simultaneous change in the interaction between the cargo and the polymer shell and the modified pore walls. At low pH, the electrostatic interaction of the cationic cargo with the protonated amine groups of the extended polymer shell retains the cargo, resulting in very low leakage (OFF state). At high pH, the electrostatic interaction with the cargo is lost (due to deprotonation of the polymer amine groups), and the polymer shell collapses, squeezing out the cargo in a burst release (ON state). Pore functionalization in combination with the stimuli-responsive polymer shell is a very promising strategy to design high-performance ON:OFF smart hybrid nanocarriers for stimuli-actuated cargo release, with great potential for application in the controlled release of drugs and other biologically active agents. MDPI 2021-05-13 /pmc/articles/PMC8153141/ /pubmed/34068257 http://dx.doi.org/10.3390/pharmaceutics13050716 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonçalves, José L. M.
Lopes, Ana Beatriz C.
Baleizão, Carlos
Farinha, José Paulo S.
Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title_full Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title_fullStr Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title_full_unstemmed Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title_short Mesoporous Silica Nanoparticles Modified inside and out for ON:OFF pH-Modulated Cargo Release
title_sort mesoporous silica nanoparticles modified inside and out for on:off ph-modulated cargo release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153141/
https://www.ncbi.nlm.nih.gov/pubmed/34068257
http://dx.doi.org/10.3390/pharmaceutics13050716
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