Cargando…

Combination of Mesenchymal Stem Cell-Delivered Oncolytic Virus with Prodrug Activation Increases Efficacy and Safety of Colorectal Cancer Therapy

Although oncolytic viruses are currently being evaluated for cancer treatment in clinical trials, systemic administration is hindered by many factors that prevent them from reaching the tumor cells. When administered systemically, mesenchymal stem cells (MSCs) target tumors, and therefore constitute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Chun-Te, Wu, Mei-Hsuan, Chen, Ming-Jen, Lin, Shih-Pei, Yen, Yu-Ting, Hung, Shih-Chieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153168/ https://www.ncbi.nlm.nih.gov/pubmed/34068264 http://dx.doi.org/10.3390/biomedicines9050548

Ejemplares similares

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
por: Yen, Yu-Ting, et al.
Publicado: (2021)

Mesenchymal Stem Cells From a Hypoxic Culture Can Improve Rotator Cuff Tear Repair
por: Chen, Hsin-Shui, et al.
Publicado: (2022)

Oncolytic viruses: finally delivering
por: Seymour, Leonard W, et al.
Publicado: (2016)

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB Pathway
por: Chou, Lun-Yin, et al.
Publicado: (2022)

Functional roles of pluripotency transcription factors in mesenchymal stem cells
por: Tsai, Chih-Chien, et al.
Publicado: (2012)

Stem Cells Delivered Oncolytic Virus to Destroy Formidable Brain Tumor
por: Balaji E, Vignesh, et al.
Publicado: (2021)

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs
por: Kasai, Kazue, et al.
Publicado: (2013)

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin
por: Yang, Der-Chih, et al.
Publicado: (2008)

Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
por: Keshavarz, Mohsen, et al.
Publicado: (2020)

Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy
por: Mahasa, Khaphetsi Joseph, et al.
Publicado: (2020)

c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells
por: Chen, Pei-Min, et al.
Publicado: (2015)

RB Maintains Quiescence and Prevents Premature Senescence through Upregulation of DNMT1 in Mesenchymal Stromal Cells
por: Lin, Shih-Pei, et al.
Publicado: (2014)

Identifying the Therapeutic Significance of Mesenchymal Stem Cells
por: Mishra, Vineet Kumar, et al.
Publicado: (2020)

Correction to: Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
por: Keshavarz, Mohsen, et al.
Publicado: (2020)

Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines
por: Tsai, Chih-Chien, et al.
Publicado: (2010)

Multiple Treatment Cycles of Neural Stem Cell Delivered Oncolytic Adenovirus for the Treatment of Glioblastoma
por: Batalla-Covello, Jennifer, et al.
Publicado: (2021)

The canine epiphyseal-derived mesenchymal stem cells are comparable to bone marrow derived-mesenchymal stem cells
por: CHANG, Ya-Pei, et al.
Publicado: (2014)

Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice
por: Chiang, Milton D., et al.
Publicado: (2022)

Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety
por: Ge, Yan, et al.
Publicado: (2020)

Self-delivering prodrug-nanoassemblies fabricated by disulfide bond bridged oleate prodrug of docetaxel for breast cancer therapy
por: Zhang, Shenwu, et al.
Publicado: (2017)

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs
por: Huo, Yuantao, et al.
Publicado: (2019)

Effects of Combinatorial Treatment with Pituitary Adenylate Cyclase Activating Peptide and Human Mesenchymal Stem Cells on Spinal Cord Tissue Repair
por: Fang, Kuan-Min, et al.
Publicado: (2010)

Mesenchymal stem cells and oncolytic viruses: joining forces against cancer
por: Moreno, Rafael
Publicado: (2021)

Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells
por: Lee, Yi-Jang, et al.
Publicado: (2010)

Involvement of mTOR-autophagy in the selection of primitive mesenchymal stem cells in chitosan film 3-dimensional culture
por: Chiu, Hsiao-Ying, et al.
Publicado: (2017)

Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report
por: Peng, Shang-Hsuan, et al.
Publicado: (2022)

Preclinical Safety Evaluation of Intranasally Delivered Human Mesenchymal Stem Cells in Juvenile Mice
por: Aguilera, Yolanda, et al.
Publicado: (2021)

Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice
por: Chang, Chao-Yuan, et al.
Publicado: (2021)

Inactivation of APC Induces CD34 Upregulation to Promote Epithelial-Mesenchymal Transition and Cancer Stem Cell Traits in Pancreatic Cancer
por: Hsieh, Mei Jen, et al.
Publicado: (2020)

A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway
por: Huang, Wei-Chieh, et al.
Publicado: (2019)

Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
por: Shen, Wen-Ching, et al.
Publicado: (2019)

Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells
por: Wei, Ming-Feng, et al.
Publicado: (2014)

Mesenchymal stem cell carriers enhance anti-tumor efficacy of oncolytic virotherapy
por: Wang, Xianyao, et al.
Publicado: (2021)

Correction: Mesenchymal stem cells and oncolytic viruses: joining forces against cancer
Publicado: (2021)

Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment
por: Ghasemi Darestani, Nadia, et al.
Publicado: (2023)

Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy
por: Tseng, Wei-Cheng, et al.
Publicado: (2021)

Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK
por: Lin, Hsiao-Yun, et al.
Publicado: (2010)

Downregulation of DAB2IP Promotes Mesenchymal-To-Neuroepithelial Transition and Neuronal Differentiation of Human Mesenchymal Stem Cells
por: Chang, Sunny Li-Yun, et al.
Publicado: (2013)

Survival of Cancer Stem Cells under Hypoxia and Serum Depletion via Decrease in PP2A Activity and Activation of p38-MAPKAPK2-Hsp27
por: Lin, Shih-Pei, et al.
Publicado: (2012)

Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy
por: Li, Fu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6j68khudvtqgtsleo42mfi7502