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Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity

The SARS-Cov-2 is a type of coronavirus that has caused the COVID-19 pandemic. In traditional epidemiological models such as SEIR (Susceptible, Exposed, Infected, Removed), the exposed group E does not infect the susceptible group S. A distinguishing feature of COVID-19 is that, unlike with previous...

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Autores principales: Ansumali, Santosh, Kaushal, Shaurya, Kumar, Aloke, Prakash, Meher K., Vidyasagar, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: , IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153201/
http://dx.doi.org/10.1016/j.ifacol.2021.04.223
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author Ansumali, Santosh
Kaushal, Shaurya
Kumar, Aloke
Prakash, Meher K.
Vidyasagar, M.
author_facet Ansumali, Santosh
Kaushal, Shaurya
Kumar, Aloke
Prakash, Meher K.
Vidyasagar, M.
author_sort Ansumali, Santosh
collection PubMed
description The SARS-Cov-2 is a type of coronavirus that has caused the COVID-19 pandemic. In traditional epidemiological models such as SEIR (Susceptible, Exposed, Infected, Removed), the exposed group E does not infect the susceptible group S. A distinguishing feature of COVID-19 is that, unlike with previous viruses, there is a distinct “asymptomatic” group A, who do not show any symptoms, but can nevertheless infect others, at the same rate as infected patients. This situation is captured in a model known as SAIR (Susceptible, Asymptomatic, Infected, Removed), introduced in Robinson and Stilianakis (2013). The dynamical behavior of the SAIR model is quite different from that of the SEIR model. In this paper, we use Lyapunov theory to establish the global asymptotic stabiilty of the SAIR model. Next, we present methods for estimating the parameters in the SAIR model. We apply these estimation methods to data from several countries including India, and show that the predicted trajectories of the disease closely match actual data.
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spelling pubmed-81532012021-05-28 Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity Ansumali, Santosh Kaushal, Shaurya Kumar, Aloke Prakash, Meher K. Vidyasagar, M. IFAC-PapersOnLine Article The SARS-Cov-2 is a type of coronavirus that has caused the COVID-19 pandemic. In traditional epidemiological models such as SEIR (Susceptible, Exposed, Infected, Removed), the exposed group E does not infect the susceptible group S. A distinguishing feature of COVID-19 is that, unlike with previous viruses, there is a distinct “asymptomatic” group A, who do not show any symptoms, but can nevertheless infect others, at the same rate as infected patients. This situation is captured in a model known as SAIR (Susceptible, Asymptomatic, Infected, Removed), introduced in Robinson and Stilianakis (2013). The dynamical behavior of the SAIR model is quite different from that of the SEIR model. In this paper, we use Lyapunov theory to establish the global asymptotic stabiilty of the SAIR model. Next, we present methods for estimating the parameters in the SAIR model. We apply these estimation methods to data from several countries including India, and show that the predicted trajectories of the disease closely match actual data. , IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. 2020 2021-05-26 /pmc/articles/PMC8153201/ http://dx.doi.org/10.1016/j.ifacol.2021.04.223 Text en © 2019, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ansumali, Santosh
Kaushal, Shaurya
Kumar, Aloke
Prakash, Meher K.
Vidyasagar, M.
Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title_full Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title_fullStr Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title_full_unstemmed Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title_short Modelling the COVID-19 Pandemic: Asymptomatic Patients, Lockdown and Herd Immunity
title_sort modelling the covid-19 pandemic: asymptomatic patients, lockdown and herd immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153201/
http://dx.doi.org/10.1016/j.ifacol.2021.04.223
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