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Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientifi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153289/ https://www.ncbi.nlm.nih.gov/pubmed/34068305 http://dx.doi.org/10.3390/jpm11050410 |
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author | Musielak, Marika Suchorska, Wiktoria M. Fundowicz, Magdalena Milecki, Piotr Malicki, Julian |
author_facet | Musielak, Marika Suchorska, Wiktoria M. Fundowicz, Magdalena Milecki, Piotr Malicki, Julian |
author_sort | Musielak, Marika |
collection | PubMed |
description | The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientific groups have conducted extensive research into the improved efficacy and lower toxicity of proton therapy for breast cancer. Unfortunately, there is no complete insight into the potential reasons and prospects for avoiding undesirable results. Cardiotoxicity is considered challenging; however, researchers have not presented any realistic prospects for preventing them. We compared the clinical evidence collected over the last 20 years, providing the rationale for the consideration of proton therapy as an effective solution to reduce cardiotoxicity. We analyzed the parameters of the dose distribution (mean dose, Dmax, V5, and V20) in organs at risk, such as the heart, blood vessels, and lungs, using the following two irradiation techniques: whole breast irradiation and accelerated partial breast irradiation. Moreover, we presented the possible causes of side effects, taking into account biological and technical issues. Finally, we collected potential improvements in higher quality predictions of toxic cardiac effects, like biomarkers, and model-based approaches to give the full background of this complex issue. |
format | Online Article Text |
id | pubmed-8153289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81532892021-05-27 Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy Musielak, Marika Suchorska, Wiktoria M. Fundowicz, Magdalena Milecki, Piotr Malicki, Julian J Pers Med Review The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientific groups have conducted extensive research into the improved efficacy and lower toxicity of proton therapy for breast cancer. Unfortunately, there is no complete insight into the potential reasons and prospects for avoiding undesirable results. Cardiotoxicity is considered challenging; however, researchers have not presented any realistic prospects for preventing them. We compared the clinical evidence collected over the last 20 years, providing the rationale for the consideration of proton therapy as an effective solution to reduce cardiotoxicity. We analyzed the parameters of the dose distribution (mean dose, Dmax, V5, and V20) in organs at risk, such as the heart, blood vessels, and lungs, using the following two irradiation techniques: whole breast irradiation and accelerated partial breast irradiation. Moreover, we presented the possible causes of side effects, taking into account biological and technical issues. Finally, we collected potential improvements in higher quality predictions of toxic cardiac effects, like biomarkers, and model-based approaches to give the full background of this complex issue. MDPI 2021-05-13 /pmc/articles/PMC8153289/ /pubmed/34068305 http://dx.doi.org/10.3390/jpm11050410 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Musielak, Marika Suchorska, Wiktoria M. Fundowicz, Magdalena Milecki, Piotr Malicki, Julian Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title | Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title_full | Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title_fullStr | Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title_full_unstemmed | Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title_short | Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy |
title_sort | future perspectives of proton therapy in minimizing the toxicity of breast cancer radiotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153289/ https://www.ncbi.nlm.nih.gov/pubmed/34068305 http://dx.doi.org/10.3390/jpm11050410 |
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