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Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy

The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientifi...

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Autores principales: Musielak, Marika, Suchorska, Wiktoria M., Fundowicz, Magdalena, Milecki, Piotr, Malicki, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153289/
https://www.ncbi.nlm.nih.gov/pubmed/34068305
http://dx.doi.org/10.3390/jpm11050410
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author Musielak, Marika
Suchorska, Wiktoria M.
Fundowicz, Magdalena
Milecki, Piotr
Malicki, Julian
author_facet Musielak, Marika
Suchorska, Wiktoria M.
Fundowicz, Magdalena
Milecki, Piotr
Malicki, Julian
author_sort Musielak, Marika
collection PubMed
description The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientific groups have conducted extensive research into the improved efficacy and lower toxicity of proton therapy for breast cancer. Unfortunately, there is no complete insight into the potential reasons and prospects for avoiding undesirable results. Cardiotoxicity is considered challenging; however, researchers have not presented any realistic prospects for preventing them. We compared the clinical evidence collected over the last 20 years, providing the rationale for the consideration of proton therapy as an effective solution to reduce cardiotoxicity. We analyzed the parameters of the dose distribution (mean dose, Dmax, V5, and V20) in organs at risk, such as the heart, blood vessels, and lungs, using the following two irradiation techniques: whole breast irradiation and accelerated partial breast irradiation. Moreover, we presented the possible causes of side effects, taking into account biological and technical issues. Finally, we collected potential improvements in higher quality predictions of toxic cardiac effects, like biomarkers, and model-based approaches to give the full background of this complex issue.
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spelling pubmed-81532892021-05-27 Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy Musielak, Marika Suchorska, Wiktoria M. Fundowicz, Magdalena Milecki, Piotr Malicki, Julian J Pers Med Review The toxicity of radiotherapy is a key issue when analyzing the eligibility criteria for patients with breast cancer. In order to obtain better results, proton therapy is proposed because of the more favorable distribution of the dose in the patient’s body compared with photon radiotherapy. Scientific groups have conducted extensive research into the improved efficacy and lower toxicity of proton therapy for breast cancer. Unfortunately, there is no complete insight into the potential reasons and prospects for avoiding undesirable results. Cardiotoxicity is considered challenging; however, researchers have not presented any realistic prospects for preventing them. We compared the clinical evidence collected over the last 20 years, providing the rationale for the consideration of proton therapy as an effective solution to reduce cardiotoxicity. We analyzed the parameters of the dose distribution (mean dose, Dmax, V5, and V20) in organs at risk, such as the heart, blood vessels, and lungs, using the following two irradiation techniques: whole breast irradiation and accelerated partial breast irradiation. Moreover, we presented the possible causes of side effects, taking into account biological and technical issues. Finally, we collected potential improvements in higher quality predictions of toxic cardiac effects, like biomarkers, and model-based approaches to give the full background of this complex issue. MDPI 2021-05-13 /pmc/articles/PMC8153289/ /pubmed/34068305 http://dx.doi.org/10.3390/jpm11050410 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Musielak, Marika
Suchorska, Wiktoria M.
Fundowicz, Magdalena
Milecki, Piotr
Malicki, Julian
Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title_full Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title_fullStr Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title_full_unstemmed Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title_short Future Perspectives of Proton Therapy in Minimizing the Toxicity of Breast Cancer Radiotherapy
title_sort future perspectives of proton therapy in minimizing the toxicity of breast cancer radiotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153289/
https://www.ncbi.nlm.nih.gov/pubmed/34068305
http://dx.doi.org/10.3390/jpm11050410
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