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Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience

Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SP...

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Autores principales: Koçer, Murat, Muallaoğlu, Sadık, Çetin, Bülent, Coşkun, Hasan Şenol, Karahan, Nermin, Gürdal, Osman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153290/
https://www.ncbi.nlm.nih.gov/pubmed/34068309
http://dx.doi.org/10.3390/medicina57050494
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author Koçer, Murat
Muallaoğlu, Sadık
Çetin, Bülent
Coşkun, Hasan Şenol
Karahan, Nermin
Gürdal, Osman
author_facet Koçer, Murat
Muallaoğlu, Sadık
Çetin, Bülent
Coşkun, Hasan Şenol
Karahan, Nermin
Gürdal, Osman
author_sort Koçer, Murat
collection PubMed
description Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SPMTs from a total of 103 patients with GISTs in a single center in Turkey. At the time of GIST diagnosis, patient age, sex, presentation symptoms, localization, pathological features of the tumor, stage, recurrence risk scoring for localized disease, treatments received, time of SPMT association, follow-up times, and survival analysis were recorded for each patient. Localization, histopathology, and stage of SPMT accompanying GISTs were also recorded accordingly. Results: SPMT was detected in 19.4% of patients with GISTs. Of the patients, 50% were men and 50% were women. The mean age at the time of diagnosis of GIST was 63.8 ± 10.81 years (range: 39–77 years). Of the GISTs, 60% were localized in the stomach, 25% in the small intestine, and 70% were at low risk. Of the SPMTs, 60% were in the gastrointestinal system. SPMTs were diagnosed as synchronous with GISTs in 50% of the patients. The mean follow-up period of the patients from the diagnosis of GIST was 45.6 (0.43–129.6) months. When the data were finalized, 5% died due to GIST, 35% died due to SPMT, and 15% died due to non-disease-related causes. Conclusions: SPMT was detected in 19.4% of patients with GISTs. GISTs were frequently located in the stomach, and most of them were at low risk. The most common SPMTs were gastrointestinal system tumors, and their coexistence was found to be synchronous. Most patients died due to SPMT during follow-up.
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spelling pubmed-81532902021-05-27 Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience Koçer, Murat Muallaoğlu, Sadık Çetin, Bülent Coşkun, Hasan Şenol Karahan, Nermin Gürdal, Osman Medicina (Kaunas) Article Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SPMTs from a total of 103 patients with GISTs in a single center in Turkey. At the time of GIST diagnosis, patient age, sex, presentation symptoms, localization, pathological features of the tumor, stage, recurrence risk scoring for localized disease, treatments received, time of SPMT association, follow-up times, and survival analysis were recorded for each patient. Localization, histopathology, and stage of SPMT accompanying GISTs were also recorded accordingly. Results: SPMT was detected in 19.4% of patients with GISTs. Of the patients, 50% were men and 50% were women. The mean age at the time of diagnosis of GIST was 63.8 ± 10.81 years (range: 39–77 years). Of the GISTs, 60% were localized in the stomach, 25% in the small intestine, and 70% were at low risk. Of the SPMTs, 60% were in the gastrointestinal system. SPMTs were diagnosed as synchronous with GISTs in 50% of the patients. The mean follow-up period of the patients from the diagnosis of GIST was 45.6 (0.43–129.6) months. When the data were finalized, 5% died due to GIST, 35% died due to SPMT, and 15% died due to non-disease-related causes. Conclusions: SPMT was detected in 19.4% of patients with GISTs. GISTs were frequently located in the stomach, and most of them were at low risk. The most common SPMTs were gastrointestinal system tumors, and their coexistence was found to be synchronous. Most patients died due to SPMT during follow-up. MDPI 2021-05-13 /pmc/articles/PMC8153290/ /pubmed/34068309 http://dx.doi.org/10.3390/medicina57050494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koçer, Murat
Muallaoğlu, Sadık
Çetin, Bülent
Coşkun, Hasan Şenol
Karahan, Nermin
Gürdal, Osman
Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title_full Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title_fullStr Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title_full_unstemmed Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title_short Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
title_sort second primary tumors in patients with gastrointestinal stromal tumors: a single-center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153290/
https://www.ncbi.nlm.nih.gov/pubmed/34068309
http://dx.doi.org/10.3390/medicina57050494
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