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Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience
Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SP...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153290/ https://www.ncbi.nlm.nih.gov/pubmed/34068309 http://dx.doi.org/10.3390/medicina57050494 |
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author | Koçer, Murat Muallaoğlu, Sadık Çetin, Bülent Coşkun, Hasan Şenol Karahan, Nermin Gürdal, Osman |
author_facet | Koçer, Murat Muallaoğlu, Sadık Çetin, Bülent Coşkun, Hasan Şenol Karahan, Nermin Gürdal, Osman |
author_sort | Koçer, Murat |
collection | PubMed |
description | Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SPMTs from a total of 103 patients with GISTs in a single center in Turkey. At the time of GIST diagnosis, patient age, sex, presentation symptoms, localization, pathological features of the tumor, stage, recurrence risk scoring for localized disease, treatments received, time of SPMT association, follow-up times, and survival analysis were recorded for each patient. Localization, histopathology, and stage of SPMT accompanying GISTs were also recorded accordingly. Results: SPMT was detected in 19.4% of patients with GISTs. Of the patients, 50% were men and 50% were women. The mean age at the time of diagnosis of GIST was 63.8 ± 10.81 years (range: 39–77 years). Of the GISTs, 60% were localized in the stomach, 25% in the small intestine, and 70% were at low risk. Of the SPMTs, 60% were in the gastrointestinal system. SPMTs were diagnosed as synchronous with GISTs in 50% of the patients. The mean follow-up period of the patients from the diagnosis of GIST was 45.6 (0.43–129.6) months. When the data were finalized, 5% died due to GIST, 35% died due to SPMT, and 15% died due to non-disease-related causes. Conclusions: SPMT was detected in 19.4% of patients with GISTs. GISTs were frequently located in the stomach, and most of them were at low risk. The most common SPMTs were gastrointestinal system tumors, and their coexistence was found to be synchronous. Most patients died due to SPMT during follow-up. |
format | Online Article Text |
id | pubmed-8153290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81532902021-05-27 Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience Koçer, Murat Muallaoğlu, Sadık Çetin, Bülent Coşkun, Hasan Şenol Karahan, Nermin Gürdal, Osman Medicina (Kaunas) Article Background and Objectives: In this study, we investigated the frequency and type of second primary malignant tumors (SPMTs) accompanying gastrointestinal stromal tumors (GISTs), patient and tumor characteristics, and follow-up and survival data. Materials and Methods: We included 20 patients with SPMTs from a total of 103 patients with GISTs in a single center in Turkey. At the time of GIST diagnosis, patient age, sex, presentation symptoms, localization, pathological features of the tumor, stage, recurrence risk scoring for localized disease, treatments received, time of SPMT association, follow-up times, and survival analysis were recorded for each patient. Localization, histopathology, and stage of SPMT accompanying GISTs were also recorded accordingly. Results: SPMT was detected in 19.4% of patients with GISTs. Of the patients, 50% were men and 50% were women. The mean age at the time of diagnosis of GIST was 63.8 ± 10.81 years (range: 39–77 years). Of the GISTs, 60% were localized in the stomach, 25% in the small intestine, and 70% were at low risk. Of the SPMTs, 60% were in the gastrointestinal system. SPMTs were diagnosed as synchronous with GISTs in 50% of the patients. The mean follow-up period of the patients from the diagnosis of GIST was 45.6 (0.43–129.6) months. When the data were finalized, 5% died due to GIST, 35% died due to SPMT, and 15% died due to non-disease-related causes. Conclusions: SPMT was detected in 19.4% of patients with GISTs. GISTs were frequently located in the stomach, and most of them were at low risk. The most common SPMTs were gastrointestinal system tumors, and their coexistence was found to be synchronous. Most patients died due to SPMT during follow-up. MDPI 2021-05-13 /pmc/articles/PMC8153290/ /pubmed/34068309 http://dx.doi.org/10.3390/medicina57050494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Koçer, Murat Muallaoğlu, Sadık Çetin, Bülent Coşkun, Hasan Şenol Karahan, Nermin Gürdal, Osman Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title | Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title_full | Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title_fullStr | Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title_full_unstemmed | Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title_short | Second Primary Tumors in Patients with Gastrointestinal Stromal Tumors: A Single-Center Experience |
title_sort | second primary tumors in patients with gastrointestinal stromal tumors: a single-center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153290/ https://www.ncbi.nlm.nih.gov/pubmed/34068309 http://dx.doi.org/10.3390/medicina57050494 |
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