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Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activ...

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Autores principales: Radomska, Dominika, Czarnomysy, Robert, Radomski, Dominik, Bielawska, Anna, Bielawski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153312/
https://www.ncbi.nlm.nih.gov/pubmed/34068374
http://dx.doi.org/10.3390/nu13051649
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author Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawska, Anna
Bielawski, Krzysztof
author_facet Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawska, Anna
Bielawski, Krzysztof
author_sort Radomska, Dominika
collection PubMed
description This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development.
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spelling pubmed-81533122021-05-27 Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawska, Anna Bielawski, Krzysztof Nutrients Review This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development. MDPI 2021-05-13 /pmc/articles/PMC8153312/ /pubmed/34068374 http://dx.doi.org/10.3390/nu13051649 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawska, Anna
Bielawski, Krzysztof
Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title_full Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title_fullStr Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title_full_unstemmed Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title_short Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
title_sort selenium as a bioactive micronutrient in the human diet and its cancer chemopreventive activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153312/
https://www.ncbi.nlm.nih.gov/pubmed/34068374
http://dx.doi.org/10.3390/nu13051649
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