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Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer

[Image: see text] As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the sing...

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Autores principales: Villa, Irene, Villa, Chiara, Crapanzano, Roberta, Secchi, Valeria, Tawfilas, Massimo, Trombetta, Elena, Porretti, Laura, Brambilla, Andrea, Campione, Marcello, Torrente, Yvan, Vedda, Anna, Monguzzi, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153399/
https://www.ncbi.nlm.nih.gov/pubmed/33719410
http://dx.doi.org/10.1021/acsami.1c02504
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author Villa, Irene
Villa, Chiara
Crapanzano, Roberta
Secchi, Valeria
Tawfilas, Massimo
Trombetta, Elena
Porretti, Laura
Brambilla, Andrea
Campione, Marcello
Torrente, Yvan
Vedda, Anna
Monguzzi, Angelo
author_facet Villa, Irene
Villa, Chiara
Crapanzano, Roberta
Secchi, Valeria
Tawfilas, Massimo
Trombetta, Elena
Porretti, Laura
Brambilla, Andrea
Campione, Marcello
Torrente, Yvan
Vedda, Anna
Monguzzi, Angelo
author_sort Villa, Irene
collection PubMed
description [Image: see text] As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
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spelling pubmed-81533992021-05-27 Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer Villa, Irene Villa, Chiara Crapanzano, Roberta Secchi, Valeria Tawfilas, Massimo Trombetta, Elena Porretti, Laura Brambilla, Andrea Campione, Marcello Torrente, Yvan Vedda, Anna Monguzzi, Angelo ACS Appl Mater Interfaces [Image: see text] As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation. American Chemical Society 2021-03-15 2021-03-24 /pmc/articles/PMC8153399/ /pubmed/33719410 http://dx.doi.org/10.1021/acsami.1c02504 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Villa, Irene
Villa, Chiara
Crapanzano, Roberta
Secchi, Valeria
Tawfilas, Massimo
Trombetta, Elena
Porretti, Laura
Brambilla, Andrea
Campione, Marcello
Torrente, Yvan
Vedda, Anna
Monguzzi, Angelo
Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title_full Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title_fullStr Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title_full_unstemmed Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title_short Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer
title_sort functionalized scintillating nanotubes for simultaneous radio- and photodynamic therapy of cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153399/
https://www.ncbi.nlm.nih.gov/pubmed/33719410
http://dx.doi.org/10.1021/acsami.1c02504
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