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Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1

Sugar, light, and hormones are major signals regulating plant growth and development, however, the interactions among these signals are not fully understood at the molecular level. Recent studies showed that sugar promotes hypocotyl elongation by activating the brassinosteroid (BR) signaling pathway...

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Autores principales: Zhang, Zhenzhen, Sun, Ying, Jiang, Xue, Wang, Wenfei, Wang, Zhi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153450/
https://www.ncbi.nlm.nih.gov/pubmed/33989283
http://dx.doi.org/10.1371/journal.pgen.1009540
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author Zhang, Zhenzhen
Sun, Ying
Jiang, Xue
Wang, Wenfei
Wang, Zhi-Yong
author_facet Zhang, Zhenzhen
Sun, Ying
Jiang, Xue
Wang, Wenfei
Wang, Zhi-Yong
author_sort Zhang, Zhenzhen
collection PubMed
description Sugar, light, and hormones are major signals regulating plant growth and development, however, the interactions among these signals are not fully understood at the molecular level. Recent studies showed that sugar promotes hypocotyl elongation by activating the brassinosteroid (BR) signaling pathway after shifting Arabidopsis seedlings from light to extended darkness. Here, we show that sugar inhibits BR signaling in Arabidopsis seedlings grown under light. BR induction of hypocotyl elongation in seedlings grown under light is inhibited by increasing concentration of sucrose. The sugar inhibition of BR response is correlated with decreased effect of BR on the dephosphorylation of BZR1, the master transcription factor of the BR signaling pathway. This sugar effect is independent of the sugar sensors Hexokinase 1 (HXK1) and Target of Rapamycin (TOR), but requires the GSK3-like kinase Brassinosteroid-Insensitive 2 (BIN2), which is stabilized by sugar. Our study uncovers an inhibitory effect of sugar on BR signaling in plants grown under light, in contrast to its promotive effect in the dark. Such light-dependent sugar-BR crosstalk apparently contributes to optimal growth responses to photosynthate availability according to light-dark conditions.
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spelling pubmed-81534502021-06-07 Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1 Zhang, Zhenzhen Sun, Ying Jiang, Xue Wang, Wenfei Wang, Zhi-Yong PLoS Genet Research Article Sugar, light, and hormones are major signals regulating plant growth and development, however, the interactions among these signals are not fully understood at the molecular level. Recent studies showed that sugar promotes hypocotyl elongation by activating the brassinosteroid (BR) signaling pathway after shifting Arabidopsis seedlings from light to extended darkness. Here, we show that sugar inhibits BR signaling in Arabidopsis seedlings grown under light. BR induction of hypocotyl elongation in seedlings grown under light is inhibited by increasing concentration of sucrose. The sugar inhibition of BR response is correlated with decreased effect of BR on the dephosphorylation of BZR1, the master transcription factor of the BR signaling pathway. This sugar effect is independent of the sugar sensors Hexokinase 1 (HXK1) and Target of Rapamycin (TOR), but requires the GSK3-like kinase Brassinosteroid-Insensitive 2 (BIN2), which is stabilized by sugar. Our study uncovers an inhibitory effect of sugar on BR signaling in plants grown under light, in contrast to its promotive effect in the dark. Such light-dependent sugar-BR crosstalk apparently contributes to optimal growth responses to photosynthate availability according to light-dark conditions. Public Library of Science 2021-05-14 /pmc/articles/PMC8153450/ /pubmed/33989283 http://dx.doi.org/10.1371/journal.pgen.1009540 Text en © 2021 Zhang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Zhenzhen
Sun, Ying
Jiang, Xue
Wang, Wenfei
Wang, Zhi-Yong
Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title_full Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title_fullStr Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title_full_unstemmed Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title_short Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1
title_sort sugar inhibits brassinosteroid signaling by enhancing bin2 phosphorylation of bzr1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153450/
https://www.ncbi.nlm.nih.gov/pubmed/33989283
http://dx.doi.org/10.1371/journal.pgen.1009540
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