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What we can and what we cannot see with extracellular multielectrodes
Extracellular recording is an accessible technique used in animals and humans to study the brain physiology and pathology. As the number of recording channels and their density grows it is natural to ask how much improvement the additional channels bring in and how we can optimally use the new capab...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153483/ https://www.ncbi.nlm.nih.gov/pubmed/33989280 http://dx.doi.org/10.1371/journal.pcbi.1008615 |
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author | Chintaluri, Chaitanya Bejtka, Marta Średniawa, Władysław Czerwiński, Michał Dzik, Jakub M. Jędrzejewska-Szmek, Joanna Kondrakiewicz, Kacper Kublik, Ewa Wójcik, Daniel K. |
author_facet | Chintaluri, Chaitanya Bejtka, Marta Średniawa, Władysław Czerwiński, Michał Dzik, Jakub M. Jędrzejewska-Szmek, Joanna Kondrakiewicz, Kacper Kublik, Ewa Wójcik, Daniel K. |
author_sort | Chintaluri, Chaitanya |
collection | PubMed |
description | Extracellular recording is an accessible technique used in animals and humans to study the brain physiology and pathology. As the number of recording channels and their density grows it is natural to ask how much improvement the additional channels bring in and how we can optimally use the new capabilities for monitoring the brain. Here we show that for any given distribution of electrodes we can establish exactly what information about current sources in the brain can be recovered and what information is strictly unobservable. We demonstrate this in the general setting of previously proposed kernel Current Source Density method and illustrate it with simplified examples as well as using evoked potentials from the barrel cortex obtained with a Neuropixels probe and with compatible model data. We show that with conceptual separation of the estimation space from experimental setup one can recover sources not accessible to standard methods. |
format | Online Article Text |
id | pubmed-8153483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81534832021-06-09 What we can and what we cannot see with extracellular multielectrodes Chintaluri, Chaitanya Bejtka, Marta Średniawa, Władysław Czerwiński, Michał Dzik, Jakub M. Jędrzejewska-Szmek, Joanna Kondrakiewicz, Kacper Kublik, Ewa Wójcik, Daniel K. PLoS Comput Biol Research Article Extracellular recording is an accessible technique used in animals and humans to study the brain physiology and pathology. As the number of recording channels and their density grows it is natural to ask how much improvement the additional channels bring in and how we can optimally use the new capabilities for monitoring the brain. Here we show that for any given distribution of electrodes we can establish exactly what information about current sources in the brain can be recovered and what information is strictly unobservable. We demonstrate this in the general setting of previously proposed kernel Current Source Density method and illustrate it with simplified examples as well as using evoked potentials from the barrel cortex obtained with a Neuropixels probe and with compatible model data. We show that with conceptual separation of the estimation space from experimental setup one can recover sources not accessible to standard methods. Public Library of Science 2021-05-14 /pmc/articles/PMC8153483/ /pubmed/33989280 http://dx.doi.org/10.1371/journal.pcbi.1008615 Text en © 2021 Chintaluri et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chintaluri, Chaitanya Bejtka, Marta Średniawa, Władysław Czerwiński, Michał Dzik, Jakub M. Jędrzejewska-Szmek, Joanna Kondrakiewicz, Kacper Kublik, Ewa Wójcik, Daniel K. What we can and what we cannot see with extracellular multielectrodes |
title | What we can and what we cannot see with extracellular multielectrodes |
title_full | What we can and what we cannot see with extracellular multielectrodes |
title_fullStr | What we can and what we cannot see with extracellular multielectrodes |
title_full_unstemmed | What we can and what we cannot see with extracellular multielectrodes |
title_short | What we can and what we cannot see with extracellular multielectrodes |
title_sort | what we can and what we cannot see with extracellular multielectrodes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153483/ https://www.ncbi.nlm.nih.gov/pubmed/33989280 http://dx.doi.org/10.1371/journal.pcbi.1008615 |
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