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Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

Intracellular iron levels are strictly regulated to support homeostasis and avoid iron-mediated ROS production. Loss of iron-sulfur cluster (ISC) synthesis can increase iron loading and promote cell death by ferroptosis. Iron-responsive element-binding proteins IRP1 and IRP2 posttranscriptionally re...

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Detalles Bibliográficos
Autores principales:	Terzi, Erdem M., Sviderskiy, Vladislav O., Alvarez, Samantha W., Whiten, Gabrielle C., Possemato, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153722/ https://www.ncbi.nlm.nih.gov/pubmed/34039609 http://dx.doi.org/10.1126/sciadv.abg4302

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