Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR) is activated. We report an intricate interplay between three transcription factors regulating the mitochondrial stress respon...

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Detalles Bibliográficos
Autores principales: Kaspar, Sophie, Oertlin, Christian, Szczepanowska, Karolina, Kukat, Alexandra, Senft, Katharina, Lucas, Christina, Brodesser, Susanne, Hatzoglou, Maria, Larsson, Ola, Topisirovic, Ivan, Trifunovic, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153728/
https://www.ncbi.nlm.nih.gov/pubmed/34039602
http://dx.doi.org/10.1126/sciadv.abf0971

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