BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

The transcriptional coactivator BRD4 has a fundamental role in transcription regulation and thus became a promising epigenetic therapeutic candidate to target diverse pathologies. However, the regulation of BRD4 by posttranslational modifications has been largely unexplored. Here, we show that BRD4...

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Detalles Bibliográficos
Autores principales: Vershinin, Zlata, Feldman, Michal, Werner, Thilo, Weil, Lital Estrella, Kublanovsky, Margarita, Abaev-Schneiderman, Elina, Sklarz, Menachem, Lam, Enid Y. N., Alasad, Khawla, Picaud, Sarah, Rotblat, Barak, McAdam, Ruth A., Chalifa-Caspi, Vered, Bantscheff, Marcus, Chapman, Trevor, Lewis, Huw D., Filippakopoulos, Panagis, Dawson, Mark A., Grandi, Paola, Prinjha, Rab K., Levy, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153730/
https://www.ncbi.nlm.nih.gov/pubmed/34039605
http://dx.doi.org/10.1126/sciadv.abf5374

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