Cargando…

Structural Characterization and Binding Studies of the Ectodomain G Protein of Respiratory Syncytial Virus Reveal the Crucial Role of pH with Possible Implications in Host–Pathogen Interactions

[Image: see text] Respiratory syncytial virus (RSV) is a leading viral pathogen causing acute lower respiratory tract infection in children. The G protein of RSV is involved in attachment with the host cell. It is a neutralizing antigen and thus a vaccine candidate. Heparan sulfate is a type of glyc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamza, Abu, Shafat, Zoya, Parray, Zahoor Ahmad, Hisamuddin, Malik, Khan, Wajihul Hasan, Ahmed, Anwar, Almajhdi, Fahad N., Farrag, Mohamed A., Mohammed, Arif Ahmed, Islam, Asimul, Parveen, Shama
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153753/ https://www.ncbi.nlm.nih.gov/pubmed/34056193 http://dx.doi.org/10.1021/acsomega.1c00800

Ejemplares similares

Structural Characterization of Ectodomain G Protein of Respiratory Syncytial Virus and Its Interaction with Heparan Sulfate: Multi-Spectroscopic and In Silico Studies Elucidating Host-Pathogen Interactions
por: Hamza, Abu, et al.
Publicado: (2021)

Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study
por: Hamza, Abu, et al.
Publicado: (2022)

Identification of the Key miRNAs and Genes Associated with the Regulation of Non-Small Cell Lung Cancer: A Network-Based Approach
por: Shafat, Zoya, et al.
Publicado: (2022)

Intrinsically disordered regions in the rodent hepevirus proteome
por: Shafat, Zoya, et al.
Publicado: (2022)

Structural Refolding and Thermal Stability of Myoglobin in the Presence of Mixture of Crowders: Importance of Various Interactions for Protein Stabilization in Crowded Conditions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Role of “dual-personality” fragments in HEV adaptation—analysis of Y-domain region
por: Shafat, Zoya, et al.
Publicado: (2021)

Analysis of codon usage patterns in open reading frame 4 of hepatitis E viruses
por: Shafat, Zoya, et al.
Publicado: (2022)

Sequence to structure analysis of the ORF4 protein from Hepatitis E virus
por: Shafat, Zoya, et al.
Publicado: (2021)

Decoding the codon usage patterns in Y-domain region of hepatitis E viruses
por: Shafat, Zoya, et al.
Publicado: (2022)

Sequence to structural analysis of ORF5 protein in Norway rat Hepatitis E Virus
por: Shafat, Zoya, et al.
Publicado: (2022)

Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid
por: Shafat, Zoya, et al.
Publicado: (2023)

BA9 lineage of respiratory syncytial virus from across the globe and its evolutionary dynamics
por: Haider, Md Shakir Hussain, et al.
Publicado: (2018)

Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins
por: Islamuddin, Mohammad, et al.
Publicado: (2021)

Insights into Fluctuations of Structure of Proteins: Significance of Intermediary States in Regulating Biological Functions
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Prevalence of Human Coronaviruses in Children and Phylogenetic Analysis of HCoV-OC43 during 2016–2022 in Riyadh, Saudi Arabia
por: Alamri, Khalid A., et al.
Publicado: (2022)

Global and local evolutionary dynamics of Dengue virus serotypes 1, 3, and 4
por: Islam, Arshi, et al.
Publicado: (2023)

Interactions Under Crowding Milieu: Chemical-Induced Denaturation of Myoglobin is Determined by the Extent of Heme Dissociation on Interaction with Crowders
por: Nasreen, Khalida, et al.
Publicado: (2020)

Effects of Ethylene Glycol on the Structure and Stability of Myoglobin Using Spectroscopic, Interaction, and In Silico Approaches: Monomer Is Different from Those of Its Polymers
por: Parray, Zahoor Ahmad, et al.
Publicado: (2020)

Ionic Liquid Green Assembly-Mediated Migration of Piperine from Calf-Thymus DNA: A New Possibility of the Tunable Drug Delivery System
por: Maurya, Neha, et al.
Publicado: (2019)

Development and Validation of Rapid In-House Diagnostic ELISA Kits for Detection of Human Orthopneumovirus in Clinical Samples
por: Aziz, Ibrahim M., et al.
Publicado: (2022)

Co-Circulation of 72bp Duplication Group A and 60bp Duplication Group B Respiratory Syncytial Virus (RSV) Strains in Riyadh, Saudi Arabia during 2014
por: Ahmed, Anwar, et al.
Publicado: (2016)

Biophysical and flavonoid-binding studies of the G protein ectodomain of group A human respiratory syncytial virus
por: Machado, Vitor Brassolatti, et al.
Publicado: (2019)

Molecular Profiling of Inflammatory Mediators in Human Respiratory Syncytial Virus and Human Bocavirus Infection
por: Alkubaisi, Noorah A., et al.
Publicado: (2023)

Sequence and phylogentic analysis of MERS-CoV in Saudi Arabia, 2012–2019
por: Farrag, Mohamed A., et al.
Publicado: (2021)

Epidemiology of respiratory viruses in Saudi Arabia: toward a complete picture
por: Farrag, Mohamed A., et al.
Publicado: (2019)

Interaction of polyethylene glycol with cytochrome c investigated via in vitro and in silico approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2021)

Development of Highly Sensitive Sandwich ELISA for the Early-Phase Diagnosis of Chikungunya Virus Utilizing rE2-E1 Protein
por: Islamuddin, Mohammad, et al.
Publicado: (2022)

Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Emergence of deadly severe acute respiratory syndrome coronavirus-2 during 2019–2020
por: Islam, Arshi, et al.
Publicado: (2020)

Size-Dependent Interplay of Volume Exclusion Versus Soft Interactions: Cytochrome c in Macromolecular Crowded Environment
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Measuring Structural Changes in Cytochrome c under Crowded Conditions Using In Vitro and In Silico Approaches
por: Parray, Zahoor Ahmad, et al.
Publicado: (2022)

Immunoinformatics-Aided Analysis of RSV Fusion and Attachment Glycoproteins to Design a Potent Multi-Epitope Vaccine
por: Dar, Hamza Arshad, et al.
Publicado: (2022)

Characterization of CD200 Ectodomain Shedding
por: Wong, Karrie K., et al.
Publicado: (2016)

Regulated Shedding of Syndecan Ectodomains by Chemokines
por: Charnaux, Nathalie, et al.
Publicado: (2006)

The signalling conformation of the insulin receptor ectodomain
por: Weis, Felix, et al.
Publicado: (2018)

Structure of Bovine CD46 Ectodomain
por: Aitkenhead, Hazel, et al.
Publicado: (2023)

Phylogenetic and Molecular Clock Analysis of Dengue Serotype 1 and 3 from New Delhi, India
por: Afreen, Nazia, et al.
Publicado: (2015)

Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration
por: Ahanger, Ishfaq Ahmad, et al.
Publicado: (2021)

Structural Insights into the Human Metapneumovirus Glycoprotein Ectodomain
por: Leyrat, Cedric, et al.
Publicado: (2014)

Structure of the EphB6 receptor ectodomain
por: Mason, Emilia O., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_107a2uftaqscg52681uefi1c2o