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Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected persons 0–4 years of age (29%) and 25–34 years of age (27%)....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Centers for Disease Control and Prevention
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153861/ https://www.ncbi.nlm.nih.gov/pubmed/34013874 http://dx.doi.org/10.3201/eid2706.203096 |
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| author | Benschop, Kimberley S.M. Broberg, Eeva K. Hodcroft, Emma Schmitz, Dennis Albert, Jan Baicus, Anda Bailly, Jean-Luc Baldvinsdottir, Gudrun Berginc, Natasa Blomqvist, Soile Böttcher, Sindy Brytting, Mia Bujaki, Erika Cabrerizo, Maria Celma, Cristina Cinek, Ondrej Claas, Eric C.J. Cremer, Jeroen Dean, Jonathan Dembinski, Jennifer L. Demchyshyna, Iryna Diedrich, Sabine Dudman, Susanne Dunning, Jake Dyrdak, Robert Emmanouil, Mary Farkas, Agnes De Gascun, Cillian Fournier, Guillaume Georgieva, Irina Gonzalez-Sanz, Ruben van Hooydonk-Elving, Jolanda Jääskeläinen, Anne J. Jancauskaite, Ruta Keeren, Kathrin Fischer, Thea K. Krokstad, Sidsel Nikolaeva–Glomb, Lubomira Novakova, Ludmila Midgley, Sofie E. Mirand, Audrey Molenkamp, Richard Morley, Ursula Mossong, Joël Muralyte, Svajune Murk, Jean-Luc Nguyen, Trung Nordbø, Svein A. Österback, Riikka Pas, Suzan Pellegrinelli, Laura Pogka, Vassiliki Prochazka, Birgit Rainetova, Petra Van Ranst, Marc Roorda, Lieuwe Schuffenecker, Isabelle Schuurman, Rob Stoyanova, Asya Templeton, Kate Verweij, Jaco J. Voulgari-Kokota, Androniki Vuorinen, Tytti Wollants, Elke Wolthers, Katja C. Zakikhany, Katherina Neher, Richard Harvala, Heli Simmonds, Peter |
| author_facet | Benschop, Kimberley S.M. Broberg, Eeva K. Hodcroft, Emma Schmitz, Dennis Albert, Jan Baicus, Anda Bailly, Jean-Luc Baldvinsdottir, Gudrun Berginc, Natasa Blomqvist, Soile Böttcher, Sindy Brytting, Mia Bujaki, Erika Cabrerizo, Maria Celma, Cristina Cinek, Ondrej Claas, Eric C.J. Cremer, Jeroen Dean, Jonathan Dembinski, Jennifer L. Demchyshyna, Iryna Diedrich, Sabine Dudman, Susanne Dunning, Jake Dyrdak, Robert Emmanouil, Mary Farkas, Agnes De Gascun, Cillian Fournier, Guillaume Georgieva, Irina Gonzalez-Sanz, Ruben van Hooydonk-Elving, Jolanda Jääskeläinen, Anne J. Jancauskaite, Ruta Keeren, Kathrin Fischer, Thea K. Krokstad, Sidsel Nikolaeva–Glomb, Lubomira Novakova, Ludmila Midgley, Sofie E. Mirand, Audrey Molenkamp, Richard Morley, Ursula Mossong, Joël Muralyte, Svajune Murk, Jean-Luc Nguyen, Trung Nordbø, Svein A. Österback, Riikka Pas, Suzan Pellegrinelli, Laura Pogka, Vassiliki Prochazka, Birgit Rainetova, Petra Van Ranst, Marc Roorda, Lieuwe Schuffenecker, Isabelle Schuurman, Rob Stoyanova, Asya Templeton, Kate Verweij, Jaco J. Voulgari-Kokota, Androniki Vuorinen, Tytti Wollants, Elke Wolthers, Katja C. Zakikhany, Katherina Neher, Richard Harvala, Heli Simmonds, Peter |
| author_sort | Benschop, Kimberley S.M. |
| collection | PubMed |
| description | In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected persons 0–4 years of age (29%) and 25–34 years of age (27%). Sequences were divided into 6 genetic clades (G1–G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections. |
| format | Online Article Text |
| id | pubmed-8153861 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Centers for Disease Control and Prevention |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81538612021-06-08 Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe Benschop, Kimberley S.M. Broberg, Eeva K. Hodcroft, Emma Schmitz, Dennis Albert, Jan Baicus, Anda Bailly, Jean-Luc Baldvinsdottir, Gudrun Berginc, Natasa Blomqvist, Soile Böttcher, Sindy Brytting, Mia Bujaki, Erika Cabrerizo, Maria Celma, Cristina Cinek, Ondrej Claas, Eric C.J. Cremer, Jeroen Dean, Jonathan Dembinski, Jennifer L. Demchyshyna, Iryna Diedrich, Sabine Dudman, Susanne Dunning, Jake Dyrdak, Robert Emmanouil, Mary Farkas, Agnes De Gascun, Cillian Fournier, Guillaume Georgieva, Irina Gonzalez-Sanz, Ruben van Hooydonk-Elving, Jolanda Jääskeläinen, Anne J. Jancauskaite, Ruta Keeren, Kathrin Fischer, Thea K. Krokstad, Sidsel Nikolaeva–Glomb, Lubomira Novakova, Ludmila Midgley, Sofie E. Mirand, Audrey Molenkamp, Richard Morley, Ursula Mossong, Joël Muralyte, Svajune Murk, Jean-Luc Nguyen, Trung Nordbø, Svein A. Österback, Riikka Pas, Suzan Pellegrinelli, Laura Pogka, Vassiliki Prochazka, Birgit Rainetova, Petra Van Ranst, Marc Roorda, Lieuwe Schuffenecker, Isabelle Schuurman, Rob Stoyanova, Asya Templeton, Kate Verweij, Jaco J. Voulgari-Kokota, Androniki Vuorinen, Tytti Wollants, Elke Wolthers, Katja C. Zakikhany, Katherina Neher, Richard Harvala, Heli Simmonds, Peter Emerg Infect Dis Research In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected persons 0–4 years of age (29%) and 25–34 years of age (27%). Sequences were divided into 6 genetic clades (G1–G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections. Centers for Disease Control and Prevention 2021-06 /pmc/articles/PMC8153861/ /pubmed/34013874 http://dx.doi.org/10.3201/eid2706.203096 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
| spellingShingle | Research Benschop, Kimberley S.M. Broberg, Eeva K. Hodcroft, Emma Schmitz, Dennis Albert, Jan Baicus, Anda Bailly, Jean-Luc Baldvinsdottir, Gudrun Berginc, Natasa Blomqvist, Soile Böttcher, Sindy Brytting, Mia Bujaki, Erika Cabrerizo, Maria Celma, Cristina Cinek, Ondrej Claas, Eric C.J. Cremer, Jeroen Dean, Jonathan Dembinski, Jennifer L. Demchyshyna, Iryna Diedrich, Sabine Dudman, Susanne Dunning, Jake Dyrdak, Robert Emmanouil, Mary Farkas, Agnes De Gascun, Cillian Fournier, Guillaume Georgieva, Irina Gonzalez-Sanz, Ruben van Hooydonk-Elving, Jolanda Jääskeläinen, Anne J. Jancauskaite, Ruta Keeren, Kathrin Fischer, Thea K. Krokstad, Sidsel Nikolaeva–Glomb, Lubomira Novakova, Ludmila Midgley, Sofie E. Mirand, Audrey Molenkamp, Richard Morley, Ursula Mossong, Joël Muralyte, Svajune Murk, Jean-Luc Nguyen, Trung Nordbø, Svein A. Österback, Riikka Pas, Suzan Pellegrinelli, Laura Pogka, Vassiliki Prochazka, Birgit Rainetova, Petra Van Ranst, Marc Roorda, Lieuwe Schuffenecker, Isabelle Schuurman, Rob Stoyanova, Asya Templeton, Kate Verweij, Jaco J. Voulgari-Kokota, Androniki Vuorinen, Tytti Wollants, Elke Wolthers, Katja C. Zakikhany, Katherina Neher, Richard Harvala, Heli Simmonds, Peter Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title_full | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title_fullStr | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title_full_unstemmed | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title_short | Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe |
| title_sort | molecular epidemiology and evolutionary trajectory of emerging echovirus 30, europe |
| topic | Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153861/ https://www.ncbi.nlm.nih.gov/pubmed/34013874 http://dx.doi.org/10.3201/eid2706.203096 |
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