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Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA

Emergence of macrolide-resistant Mycoplasma pneumoniae (MRMp) challenges empiric macrolide therapy. Our goal was to determine MRMp rates and define characteristics of children infected with macrolide-sensitive M. pneumoniae (MSMp) versus MRMp in Ohio, USA. We cultured PCR-positive M. pneumoniae spec...

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Autores principales: Lanata, Mariana M., Wang, Huanyu, Everhart, Kathy, Moore-Clingenpeel, Melisa, Ramilo, Octavio, Leber, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153876/
https://www.ncbi.nlm.nih.gov/pubmed/34013867
http://dx.doi.org/10.3201/eid2706.203206
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author Lanata, Mariana M.
Wang, Huanyu
Everhart, Kathy
Moore-Clingenpeel, Melisa
Ramilo, Octavio
Leber, Amy
author_facet Lanata, Mariana M.
Wang, Huanyu
Everhart, Kathy
Moore-Clingenpeel, Melisa
Ramilo, Octavio
Leber, Amy
author_sort Lanata, Mariana M.
collection PubMed
description Emergence of macrolide-resistant Mycoplasma pneumoniae (MRMp) challenges empiric macrolide therapy. Our goal was to determine MRMp rates and define characteristics of children infected with macrolide-sensitive M. pneumoniae (MSMp) versus MRMp in Ohio, USA. We cultured PCR-positive M. pneumoniae specimens and sequenced M. pneumoniae–positive cultures to detect macrolide resistance mutations. We reviewed medical records to compare characteristics of both groups. We identified 14 (2.8%) MRMp and 485 (97.2%) MSMp samples. Patients in these groups had similar demographics and clinical characteristics, but patients with MRMp had longer hospitalizations, were more likely to have received previous macrolides, and were more likely to have switched to alternative antimicrobial drugs. MRMp-infected patients also had ≈5-fold greater odds of pediatric intensive care unit admission. Rates of MRMp infections in children in central Ohio are low, but clinicians should remain aware of the risk for severe illness caused by these pathogens.
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spelling pubmed-81538762021-06-08 Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA Lanata, Mariana M. Wang, Huanyu Everhart, Kathy Moore-Clingenpeel, Melisa Ramilo, Octavio Leber, Amy Emerg Infect Dis Research Emergence of macrolide-resistant Mycoplasma pneumoniae (MRMp) challenges empiric macrolide therapy. Our goal was to determine MRMp rates and define characteristics of children infected with macrolide-sensitive M. pneumoniae (MSMp) versus MRMp in Ohio, USA. We cultured PCR-positive M. pneumoniae specimens and sequenced M. pneumoniae–positive cultures to detect macrolide resistance mutations. We reviewed medical records to compare characteristics of both groups. We identified 14 (2.8%) MRMp and 485 (97.2%) MSMp samples. Patients in these groups had similar demographics and clinical characteristics, but patients with MRMp had longer hospitalizations, were more likely to have received previous macrolides, and were more likely to have switched to alternative antimicrobial drugs. MRMp-infected patients also had ≈5-fold greater odds of pediatric intensive care unit admission. Rates of MRMp infections in children in central Ohio are low, but clinicians should remain aware of the risk for severe illness caused by these pathogens. Centers for Disease Control and Prevention 2021-06 /pmc/articles/PMC8153876/ /pubmed/34013867 http://dx.doi.org/10.3201/eid2706.203206 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Lanata, Mariana M.
Wang, Huanyu
Everhart, Kathy
Moore-Clingenpeel, Melisa
Ramilo, Octavio
Leber, Amy
Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title_full Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title_fullStr Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title_full_unstemmed Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title_short Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA
title_sort macrolide-resistant mycoplasma pneumoniae infections in children, ohio, usa
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153876/
https://www.ncbi.nlm.nih.gov/pubmed/34013867
http://dx.doi.org/10.3201/eid2706.203206
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