Serotype-Switch Variant of Multidrug-Resistant Streptococcus pneumoniae Sequence Type 271

We discovered 3 invasive, multidrug-resistant Streptococcus pneumoniae isolates of vaccine-refractory capsular serotype 3 that recently arose within the successful sequence type 271 complex through a serotype switch recombination event. Mapping genomic recombination sites within the serotype 3/seque...

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Detalles Bibliográficos
Autores principales: Scherer, Erin M., Beall, Bernard, Metcalf, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153891/
https://www.ncbi.nlm.nih.gov/pubmed/33915076
http://dx.doi.org/10.3201/eid2706.203629
Descripción
Sumario:We discovered 3 invasive, multidrug-resistant Streptococcus pneumoniae isolates of vaccine-refractory capsular serotype 3 that recently arose within the successful sequence type 271 complex through a serotype switch recombination event. Mapping genomic recombination sites within the serotype 3/sequence type 271 progeny revealed a 55.9-kb donated fragment that encompassed cps3, pbp1a, and additional virulence factors.

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