Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors

[Image: see text] DNA nanotechnology is undergoing rapid progress in the assembly of functional devices with biological relevance. In particular, currently, the research attention is more focused on the application of nanodevices at the interface of chemistry and biology, on the cell membrane where...

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Autores principales: Freage, Lina, Boykoff, Natalie, Mallikaratchy, Prabodhika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154169/
https://www.ncbi.nlm.nih.gov/pubmed/34056390
http://dx.doi.org/10.1021/acsomega.1c01513
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author Freage, Lina
Boykoff, Natalie
Mallikaratchy, Prabodhika
author_facet Freage, Lina
Boykoff, Natalie
Mallikaratchy, Prabodhika
author_sort Freage, Lina
collection PubMed
description [Image: see text] DNA nanotechnology is undergoing rapid progress in the assembly of functional devices with biological relevance. In particular, currently, the research attention is more focused on the application of nanodevices at the interface of chemistry and biology, on the cell membrane where protein receptors communicate with the extracellular environment. This review explores the use of multivalent nucleic acid ligands termed aptamers in the design of DNA-based nanodevices to probe cellular interactions followed by a perspective on the untapped utility of XNA and UBP nanotechnology in designing functional nanomaterials with broader structural space.
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spelling pubmed-81541692021-05-27 Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors Freage, Lina Boykoff, Natalie Mallikaratchy, Prabodhika ACS Omega [Image: see text] DNA nanotechnology is undergoing rapid progress in the assembly of functional devices with biological relevance. In particular, currently, the research attention is more focused on the application of nanodevices at the interface of chemistry and biology, on the cell membrane where protein receptors communicate with the extracellular environment. This review explores the use of multivalent nucleic acid ligands termed aptamers in the design of DNA-based nanodevices to probe cellular interactions followed by a perspective on the untapped utility of XNA and UBP nanotechnology in designing functional nanomaterials with broader structural space. American Chemical Society 2021-05-04 /pmc/articles/PMC8154169/ /pubmed/34056390 http://dx.doi.org/10.1021/acsomega.1c01513 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Freage, Lina
Boykoff, Natalie
Mallikaratchy, Prabodhika
Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title_full Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title_fullStr Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title_full_unstemmed Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title_short Utility of Multivalent Aptamers to Develop Nanoscale DNA Devices against Surface Receptors
title_sort utility of multivalent aptamers to develop nanoscale dna devices against surface receptors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154169/
https://www.ncbi.nlm.nih.gov/pubmed/34056390
http://dx.doi.org/10.1021/acsomega.1c01513
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